The 2'-hydroxyl substituent of Cyd stabilizes the anti oriented bidentate conformers of [Cyd+Na] + , and enables formation of a 2'OH 3'OH hydrogen-bonding interaction. The 2'-hydroxyl substituent is found to stabilize the glycosidic bond of Cyd vs. that of dCyd for both the protonated ...
Monofunctional DNA glycosylases hydrolyze theN-glycosidic bond to liberate the target base, while bifunctional glycosylases mediate glycosyl transfer using an amine group of the enzyme, generating a Schiff base intermediate that facilitates their second activity, cleavage of the DNA backbone. Here we ...
This leads us to ask: does a simpler, more direct reaction pathway exists which allows for the one-pot synthesis of nucleosides via formation of the β-glycosidic bond between separately preformed sugar and nucleobase moieties? The same question was asked by Orgel and collaborators more than 40 ...
JOURNAL OF MOLECULAR STRUCTUREP. Cysewski, D. Bira, K. Białkowski, An ab initio quantum chemistry study on N-glycosidic bond stabilities of hydroxyl radical modified guanosine analogs. J. Mol. Struct. THEO- CHEM 678, 77-81 (2004).
As the A2660 region has been shown to interact with the elongation factors EF-Tu and EF-G these results indicate that MAP cleaves the N-glycosidic bond at A2660 in E. coli 23 S RNA resulting in the inactivation of the ribosome. 展开 关键词: RIBOSOME RIBOSOMAL-RNA N-GLYCOSIDASE RIBOSOME-...
Glycosidic bond cleavage of pyrimidine nucleosides by low-energy electrons: a theoretical rationale DNA damage by attachment of low-energy secondary electrons is a very interesting and important mechanism. Electron capture and subsequent base release are thought to be the elementary steps of this ...
S.; Qiu, D.; Riopel, M. A.; Koganty, R. R. Steric control of N-acetylgalactosamine in glycosidic bond formation. Tetrahedron Lett. 1995, 36, 6839-6842.Steric control of N-acetylgalactosamine in glycosidic bond formation. Yule J E,Koganty R R. Tetrahedron Letters . 1995...
ait hydrolyses the β-(1,4)-glycosidic bond between the alternating N-acetylmuramic acid (NAM) and N-acetylglucosamine (NAG) in the peptidoglycan 它在peptidoglycan(水解)β- 1,4 - glycosidic债券在 (交替的) N-acetylmuramic酸 (NAM) 和N-acetylglucosamine老马之间[translate]...
aIts antibacterial mechanism is that it hydrolyses the β-(1,4)-glycosidic bond in the alternating N-acetylmuramic acid (NAM) and N-acetylglucosamine (NAG) of the peptidoglycan, causing rupture of Gram positive bacteria cell walls under the effect of osmotic pressure,and the occurrence of ...
After the hydrolysis of the N-glycosyl bond between a damaged base and C1' of a deoxyribosyl moiety of DNA, human alkyladenine DNA glycosylase (AAG) and Escherichia coli 3-methyladenine DNA glycosylase II (AlkA) bind tightly to their abasic DNA products, potentially protecting these reactive sp...