N-alkylationreaction routereaction mechanismDevelopment of highly active heterogeneous catalysts with strong acidity and mesoporous structure is a highly attractive strategy for organic synthesis. In this study, a mesoporous zeolite beta (HBeta-M) with bulky particle size and strong acidity was ...
The alkylation of aromatic amines in the presence of inorganic bases is accelerated by a PT catalyst even if KHCO3 is the base. ArNRθ ions seem not to be involved. A novel type of mechanism for a PTC process is proposed.DOI: 10.1016/S0040-4039(01)80801-7 被...
文献详情: Enantioselective Reductive N-Cyclization–Alkylation Reaction of Alkene-Tethered Oxime Esters and Alkyl Iodides by Nickel Catalysis. Xue-Gong Jia, Qi-Wei Yao, Xing-Zhong Shu*. J. Am. Chem. Soc. 2022, https://doi.org/10.1021/jacs.2c05523...
Enantioselective Reductive N-Cyclization–Alkylation Reaction of Alkene-Tethered Oxime Esters and Alkyl Iodides by Nickel Catalysis. Xue-Gong Jia, Qi-Wei Yao, Xing-Zhong Shu*.J. Am. Chem. Soc.2022, https://doi.org/10.1021/jacs.2c05523
Neda I, Melnicky C, Vollbrecht A, Schmutzler R. An Unusual N-Alkylation Reaction During the Oxidative Addition of Hexafluoroacetone and Tetrachloro-o-benzoquinone to P-Bis(2-chloroethyl) amino-Substituted λ3P-Compounds. Synthesis, 1996, (4): 473~474...
Scheme 4. Proposed mechanism(图片来源:J. Am. Chem. Soc.) 总结 舒兴中课题组报道了一例镍催化非活性烯烃与肟酯和碘代烷烃的不对称N-环化烷基化反应。该项工作揭示了杂环化应用于烯烃不对称还原双官能团化反应的可能性,实现了肟酯的高对...
Mono- and di-alkylation occur depending on the conditions. The method is of general applicability with the exception of C1 products (formamide or methanol). The mechanism is assumed to involve an aldehyde pathway.DOI: 10.1016/0304-5102(89)80257-3 ...
ChemInform Abstract: N‐ALKYLATION OF AMINO ACID RESIDUES BY CHLOROMETHYL GROUPS. A POTENTIAL SIDE REACTION IN THE SOLID PHASE PEPTIDE SYNTHESISamino acids, peptidesDie Merrifield-Peptid-Synthesekann durch nicht veresterte Chlormethyl-Gruppen am Harz empfindlich gestrt werden.doi:10.1002/chin.197907324...
reaction mechanism imply the alkyl amine substrates serve as a ligand of iridium strengthened by a (N)H-O(P) hydrogen-bonding attraction, and the hydride addition occurs via an outer-sphere transition state, in which the Cl-H H-bonding plays an important role. Through this concise procedure,...
The nucleophile 4-( p -nitrobenzyl)pyridine (NBP), a trap for alkylating agents, was used as an alkylation substrate. Conclusions were drawn as follows: (i) the mechanism of the alkylation reaction of NBP by phenylnitrosourea is different from that caused by other nitrosoureas; (ii) the ...