The aim of the current study was to investigate prognostic value ofWilms' tumor-1 (WT1)genotypes and human myeloid inhibitory C-type lectin-like (hMICL) receptor expression in normal-cytogenetic group of patients with AML. Genotyping of WT1 mutations was done by Rotor Gene real-time polymerase...
Define Myeloid cells. Myeloid cells synonyms, Myeloid cells pronunciation, Myeloid cells translation, English dictionary definition of Myeloid cells. n. A large cell of the bone marrow that is a precursor of the neutrophils and other granulocytes of the
Modulation of monosodium urate crystal-induced responses in neutrophils by the myeloid inhibitory C-type lectin-like receptor: potential therapeutic implications. Arthritis Res Ther 2013;15:R73. PMID: PM:23837669Gagne V, Marois L, Levesque JM, Galarneau H, Lahoud MH, Caminschi I et al. ...
Some of C-type lectin-like molecules possess activating/inhibitory signalling motifs that trigger downstream signalling events, suggesting the role for these receptors as positive/negative regulators of granulocyte and monocyte functions. With the exception of a few myeloid NK-like lectins, the natural ...
The C-type lectin domain family 12 member A (Clec12A/MICL) is an inhibitory receptor encoded in the Dectin-1 cluster. It is widely expressed in myeloid cel... K Neumann,J Ruland - Springer Japan 被引量: 0发表: 2016年 C-type lectin-like receptors on myeloid cells. Host defence against...
The prognostic impact of Wilms tumor-1 polymorphism (rs16754) and human myeloid inhibitory C-type lectin-like receptor expression in cytogenetically normal-acute myeloid leukemia Hanan M. Bedair Mohamed H. Attia Hatem Rabie Egyptian Journal of Medical Human Genetics (2021) Anti-leukemia effect ...
the characterization of C-type lectin receptors in innate immunity requires the identification of accompanying signaling motifs. Here we focus on the known signaling pathways of myeloid C-type lectins and on their possible functions as autonomous activating or inhibitory receptors involved in innate respo...
[209]. In a mouse tumor model, treatment with tazemetostat alone had limited inhibitory effects on HNSCC progression. However, the combination of tazemetostat and sunitinib reduced the number of MDSCs and Tregs, promoted intratumoral T-cell infiltration, inhibited T-cell exhaustion, increased ...
Here we focus on the known signaling pathways of myeloid C-type lectins and on their possible functions as autonomous activating or inhibitory receptors involved in innate responses to pathogens or self. 展开 DOI: 10.1038/ni1417 被引量: 185 ...
Like T cells, myeloid cells also express inhibitory molecules, known as immune checkpoints. These checkpoints can extensively influence various functions of myeloid cells, including proliferation, migration, differentiation, and cytotoxicity [4,5]. Blocking myeloid immune checkpoints is an effective strat...