Indeed, EDEMs and Htm1 were recently found to possess α-mannosidase activity (48, 49, 50), whereas OS-9 and Yos9 were shown to be lectins involved in the recognition of the N-glycosylated substrate (51, 52). We found that the effects of Yos9, Htm1, and Png1 were N-glycan-...
The resulting Man8GlcNAc2 isomer B would have been recognized by ER lectins like protein OS-9 and XTP3B [7]. Successively, they would be transferred back to the cytosol through the retrotranslocon, handed to the ubiquitination machinery and destroyed by the 26S proteasome. Later, it was ...