Avoidance of apoptosis is critical for the development and sustained growth of tumours. The pro-survival protein myeloid cell leukaemia 1 (Mcl-1) is overexpressed in many cancers, but the development of small molecules targeting this protein that are amenable for clinical testing...
Myeloid cell leukemia 1protein kinase signalingSRC family kinasesMyeloid cell leukemia-1 (MCL-1), closely related to B-cell lymphoma 2 (BCL-2), has a well-established role in cell survival and has emerged as an important target for cancer therapeutics. We have demonstrated that inhibiting MCL...
HIF-1 activates the expression of antiapoptotic target genes to protect Leydig cells from apoptosis. In silico analysis of testis genes containing a consensus hypoxia response element (HRE, 5'-RCGTG-3') identified myeloid cell leukemia-1 (Mcl-1) as a potential HIF-1 target gene. The pu...
上海玉博生物科技有限公司 主要致力于“Anti-Mcl-1(myeloid cell leukemia 1) 髓样细胞白血病-1抗体 yb-1352R”的生产销售。多年的“Anti-Mcl-1(myeloid cell leukemia 1) 髓样细胞白血病-1抗体 yb-1352R”生产与销售的经验,与各行业新老用户建立了稳定的合作关系,我公
Induced myeloid leukemia cell differentiation protein Mcl-1 ELISA Kit 的详细说明书 检测范围: 1.56-100 U/mL 使用:本试剂仅供科研使用 保存: 2-8 ℃ 有效期: 6 个月 检测方法: ELISA 产品性状: 96T/48T ,盒装
Background: Myeloid cell leukemia-1 (Mcl-1) is a member of the B-cell lymphoma 2 family known to play a significant role in the regulation of apoptosis. Mcl-1 expression has been studied in nonsmall cell lung cancer (NSCLC) cell lines but has not been previously evaluated as a prognosti...
内容提示: RESEARCH ARTICLEMyeloid cell leukemia 1 (Mcl−1) protects against1-methyl-4-phenylpyridinium ion (MPP+) inducedapoptosis in Parkinson’s diseaseLijing Fan1& Li Jiang1& Zhongde Du1Received: 4 February 2015 /Accepted: 4 June 2015 /Published online: 13 August 2015#Springer Science+...
英文名称:Anti-Mcl-1(myeloid cell leukemia 1) peptide货号:BY-1352P本公司经销Mcl-1(myeloid cell leukemia 1) peptide抗原,髓样细胞白血病-1抗原,并研发代理近万种抗体产品,保证Mcl-1(myeloid cell leukemia 1) peptide抗原,髓样细胞白血病-1抗原产品质量,质量稳定,实验效果明显,代理众多知名品牌抗体abcam,CST...
Mcl-1: myeloid cell leukemia-2 TNBC: triple-negative breast cancer ER: estrogen receptor PR: progesterone receptor HER2: human epidermal growth factor receptor-2 Bcl-2: B-cell CLL/lymphoma 2 Bcl-xL: Bcl-2-like protein 1 isoform 1 BH3: Bcl-2 homology domain 3 siRNA: small-...
From this family, myeloid cell leukemia-1 (Mcl-1) has proven the most difficult to target, and one of the leading causes of treatment resistance. Exploiting the selective PPI between the apoptosis-regulating protein Noxa and Mcl-1, utilising a fluorescence polarization assay, we have identified ...