It is also one of the most common cancers in children and adults younger than 20 years. The survival rate is higher for younger people. Leukemia is a group of cancers of the blood affecting the white blood cells. White blood cells are the infection-fighting cells of the body. In leukem...
The classification system of mastocytosis needs continuous refinements. In the current update, several new definitions have been introduced. For example, sub-variants of mast cell leukemia (MCL) have been recognized and added. Well-known is the separation of “leukemic” MCL (by definition circulati...
Recent trends in the management of patients with mantle cell lymphoma (MCL), including the use of intensive chemo-immunotherapy regimens, have led to high overall and complete response rates, and prolongation of progression-free survival (PFS) when first response is consolidated with high-dose ...
Hematology tests includetests on the blood, blood proteins and blood-producing organs. These tests can evaluate a variety of blood conditions including infection, anemia, inflammation, hemophilia, blood-clotting disorders, leukemia and the body's response to chemotherapy treatments. What is the most c...
When combined with ascorbic acid — also known as vitamin C or citric acid — the preservative converts to benzene, a carcinogen reported to causeleukemia, DNA damage, damage to mitochondria in cells, cell death and Attention DeficitHyperactivityDisorder (ADHD). Additional studies show that sodium...
For example, the success of imatinib for chronic myeloid leukemia (CML) is the best example of how advances in technology informed the development of a highly clinically important biomarker discovery. The Philadelphia chromosome discovery was first reported by David Hungerford and Peter Nowell, based ...
Samalizumab, a CD200 immune checkpoint inhibi- tor, showed favorable results in a phase I clinical trial of patients with chronic lymphocytic leukemia [258]. Other CAF markers Several other markers have been found to be highly expressed in CAFs. Microfibril-associated protein 5 (MFAP5) is ...
Survivin (also named BIRC5) is a well-known cancer therapeutic target. Since its discovery more than two decades ago, the use of survivin as a target for cancer therapeutics has remained a central goal of survivin studies in the cancer field. Many studie
esterases cleave the acetate groups converting CFSE into a fluorescent, membrane impermeant dye. Not transferred to adjacent cells. Retained by the cell in the cytoplasm Does not adversely affect cellular function During each round of cell division, the relative intensity of the dye is decreased by...
The normal RBC range for men is 4.7 to 6.1 million cells per microliter (cells/mcL) and the normal RBC range for women is 4.2 to 5.4 million cells/mcL. Women usually have a lower RBC count than men. Also, the total RBC count tends to decrease with age....