Hematology tests includetests on the blood, blood proteins and blood-producing organs. These tests can evaluate a variety of blood conditions including infection, anemia, inflammation, hemophilia, blood-clotting disorders, leukemia and the body's response to chemotherapy treatments. What is the most c...
Recent trends in the management of patients with mantle cell lymphoma (MCL), including the use of intensive chemo-immunotherapy regimens, have led to high overall and complete response rates, and prolongation of progression-free survival (PFS) when first response is consolidated with high-dose ...
Mcl-1 is overexpressed in multiple myeloma and associated with relapse and shorter survival. Leukemia 2005, 19, 1248–1252. [Google Scholar] [CrossRef] [Green Version] Teoh, P.J.; Chung, T.H.; Chng, P.Y.Z.; Toh, S.H.M.; Chng, W.J. IL6R-STAT3-ADAR1 (P150) interplay promotes...
The growth, differentiation, and survival of HSC have been shown to depend on the relative basal expression level of cyclins, cyclin-dependent kinases (cdks), and cdk-inhibitors (cdkis) [25,44]. Lymphoid progenitor cells from childhood acute lymphoblastic leukemia are functionally deficient and ex...
Chronic lymphocytic leukemia/small lymphocytic lymphoma is common in persons of predominately European descent but rare in Asians. Why is unknown but is likely genetically-determined. Environmental factors may also operate but are likely to be less important. When CLL occurs in Asians it has differen...
Cancers such as leukemia or lymphoma Overactive or enlarged spleen How does hemolysis affect red blood cell count? Hemolysis causes a drop in the red blood cell count, which can lead to hemolytic anemia if not diagnosed and treated. What is the role of the spleen in hemolysis? The spleen ...
Immunogenetic analysis of mantle cell lymphoma (MCL) has offered important evidence helping to decipher the immune pathways leading to its development and also prompting a reappraisal of the views about its ontogeny. In particular, older and more recent studies have demonstrated that MCL is characteri...
Notably, the sensitivity of venetoclax correlated with higher BCL-2 expression, with a BCL-2 high status [i.e. BCL-2 gains, BCL-2 amplifications, or the t translocation, which is a notable cause of deregulated BCL-2 expression] and higher BCL-2/MCL-1 ratios being potentially predictive ...
Ibrutinib is a novel targeted therapy for certain cancers of white blood cells (Mantle cell lymphoma [MCL], chronic lymphocytic leukemia [CLL]/small lymphocytic lymphoma [SLL], Waldenstrom’s macroglobulinemia [WM], marginal zone lymphoma [MZL]) in adults and is also used for the treatment of ...
When combined with ascorbic acid — also known as vitamin C or citric acid — the preservative converts to benzene, a carcinogen reported to causeleukemia, DNA damage, damage to mitochondria in cells, cell death and Attention DeficitHyperactivityDisorder (ADHD). Additional studies show that sodium...