Mechanism of actionMycophenolic acid (MPA) is a potent inhibitor of inosine monophosphate dehydrogenase (IMPDH) that prevents the ab initio biosynthesis of purine nucleotides. It predominantly affects lymphocytes, leading to inhibition of DNA synthesis in T cells and B cells, thereby suppressing cell-...
Mycophenolic acid prodrugs are effective in rheumatoid arthritis and for the prevention of organ transplant rejection. Mechanism of action is inhibition of inosine-5'-monophosphate dehydrogenase. Product SpecificationAlternative Name: 6-(4-Hydroxy-6-methoxy-7-methyl-3-oxo-5-phthalanyl)-4-methyl-4-...
The main mechanism of action of MPA is the inhibition of inosinic acid dehydrogenase (IMPDH) and thereby the inhibition of purine nucleotide synthesis [120]. Human IMPDH is expressed in two isoforms whereby MPA is more potently inhibiting the type II isoform [121]. As outlined for thiopurines,...
However, few attempts have been undertaken to delineate its mechanism of action in systemic lupus erythematosus (SLE) a disease characterized by enhanced B cell activation. Methods Clinical and paraclinical parameters of 107 patients with SLE were recorded consecutively and analyzed retrospectively. ...
However, few attempts have been undertaken to delineate its mechanism of action in systemic lupus erythematosus (SLE) a disease characterized by enhanced B cell activation. Methods Clinical and paraclinical parameters of 107 patients with SLE were recorded consecutively and analyzed retrospectively. ...
Mechanism of action of mycophenolate mofetil. Ther Drug Monit 1995; 17: 681–4. 6 Allison AC, Eugui EM. Mycophenolate mofetil and its mechanisms of action. Immunopharmacology 2000; 47: 85–118. 7 Stritesky GL, Yeh N, Kaplan MH. IL-23 promotes maintenance but not commitment to the Th17 ...
We have previously shown that mycophenolic acid (MPA), an immunomodulator, has antiviral activity against influenza A/WSN/1933(H1N1) using a high-throughput chemical screening assay. This study further investigated the antiviral activity and mechanism of action of MPA against contemporary clinical ...
Rokuro Masuma, Satoshi Oළ mura, Haruo Tanaka Received: June 2, 2005 / Accepted August 13, 2005 © Japan Antibiotics Research Association Abstract Mycophenolic acid (MPA) was identified as an inhibitor of syncytium formation during the screening of human immunodeficiency virus (HIV) entry inhib...
The protective effect of mycophenolate mofetil on the damage in renal tubulo-interstitium of diabetic rats and its mechanism of action; 霉酚酸酯对糖尿病大鼠肾小管-间质损伤的保护作用及机制 更多例句>> 4) MMF 霉酚酸酯 1. Aim To investigate the effect of mycophenolate mofetil(MMF)on the expres...
This review outlines the mechanism of action of mycophenolic acid in transplantation. Its main side effects (gastrointestinal) often lead to dose reduction... M Salvadori,E Bertoni - 《Therapy》 被引量: 3发表: 2006年 Mathematical Equations to Calculate True Mycophenolic Acid Concentration in Human ...