Mycphenolate mofetil is a suppressor of T cell proliferation and adhesion. Its primary mode of action is inhibition of inosine monophosphate dehydrogenase, a purine salvage pathway required by T lymphocytes. Although the role of T cells in rheumatoid arthritis (RA) has been controversial, a ...
Our results suggest that because of its different mode of action, mycophenolate mofetil may be able to further decrease the severity of chronic rejection not only after rat heart transplantation but also in human cardiac transplantation. 展开
Mycphenolate mofetil is a suppressor of T cell proliferation and adhesion. Its primary mode of action is inhibition of inosine monophosphate dehydrogenase, a purine salvage pathway required by T lymphocytes. Although the role of T cells in rheumatoid arthritis (RA) has been controversial, a prelimi...
Currently, mycophenolate mofetil is indicated for the prevention of organ rejection in transplant patients. The mode of action and the pharmacology of mycophenolate mofetil are reviewed and the current clinical experience with this immunosuppressive drug for dermatological disorders is summarized. 展开 ...
Review of the pharmacology and mode of action of mycophenolate mofetil MMF is the 2-morpholinoethyl ester derivative of mycophe- nolic acid (MPA), a weak organic acid produced by several Penicillium species (Allison and Eugui 2000). MMF has excellent oral bioavailability of 94.1% in healthy ...
Although their main mode of action is immunomodulatory they also have a significant antiproteinuric effect which is attributed to their haemodynamic effect on glomerular perfusion as well as to their direct effect on podocytes [12, 14]. A study comparing tacrolimus to placebo showed that TAC alone...
A case of immune-mediated glomerulonephritis that was refractory to conventional immunotherapy is reported in a dog. The case responded to a combination of mycophenolate mofetil, benazepril and aspirin. The mode of action of these drugs ... Y Li - 《Alternative Therapies in Health & Medicine》 ...
Treatment of Discoid Skin Lesions With Azathioprine-Reply and atabrine at appropriate dosages as a mode of therapy is effective and safe in recalcitrant cutaneous lupus, data concerning either the efficacy or the toxicity of this recommended combined mode of therapy are not available in the ... ...
Mycophenolate mofetil is the morpholinoethyl ester prodrug of mycophenolic acid, an uncompetitive reversible inhibitor of the rate-limiting enzyme in de no
The mass selective detection was run in the selected ion monitoring mode. Monitored ions included m/z 365 for the (M+H+) ion of XMP, m/z 348 for the (M+H+) ion of adenosine monophosphate, and m/z 426 for the (M+H+) ion of 8-bromo adenosine 5′-monophosphate, the internal ...