Wu JC. Mycophenolate mofetil: molecular mechanisms of action. Perspect Drug Discov Des 1994;2:185-204.Wu JC. Mycophenolate mofetil: molecular mechanisms of action. Perspect Drug Disc Design 1994; 2: 185.Wu JC. Mycophenolate mofetil: molecular mechanisms of action. Perspectives in Drug Discovery ...
Mycophenolate mofetil is an inosine monophosphate dehydrogenase inhibitor used to prevent the rejection of kidney, heart, or liver transplants. Brand Names Cellcept, Myfenax, Myhibbin Generic Name Mycophenolate mofetil DrugBank Accession Number DB00688 Background Mycophenolate mofetil, also known as MMF...
Mycphenolate mofetil is a suppressor of T cell proliferation and adhesion. Its primary mode of action is inhibition of inosine monophosphate dehydrogenase, a purine salvage pathway required by T lymphocytes. Although the role of T cells in rheumatoid arthritis (RA) has been controversial, a prelimi...
Although their main mode of action is immunomodulatory they also have a significant antiproteinuric effect which is attributed to their haemodynamic effect on glomerular perfusion as well as to their direct effect on podocytes [12, 14]. A study comparing tacrolimus to placebo showed that TAC alone...
Mycophenolate mofetil has an increased bioavailability as compared to mycophenolic acid and thereby an improved therapeutic window. Currently, mycophenolate mofetil is indicated for the prevention of organ rejection in transplant patients. The mode of action and the pharmacology of mycophenolate mofetil are...
Mycophenolate mofetil: complementary immunosuppressant action. Drugs Ther. Perspect 4, 7–8 (1994). https://doi.org/10.2165/00042310-199404020-00003 Download citation Published14 November 2012 Issue DateJuly 1994 DOIhttps://doi.org/10.2165/00042310-199404020-00003 Keywords Streptokinase Mycophenolate Mo...
Review of the pharmacology and mode of action of mycophenolate mofetil MMF is the 2-morpholinoethyl ester derivative of mycophe- nolic acid (MPA), a weak organic acid produced by several Penicillium species (Allison and Eugui 2000). MMF has excellent oral bioavailability of 94.1% in healthy ...
Our results suggest that because of its different mode of action, mycophenolate mofetil may be able to further decrease the severity of chronic rejection not only after rat heart transplantation but also in human cardiac transplantation. 展开
Mycophenolate mofetil is indicated for the prophylaxis of organ rejection, in adult and pediatric recipients 3 months of age and older of allogeneic kidney [see Clinical Studies (14.1)], heart [see Clinical Studies (14.2)] or liver transplants [see Clinical Studies (14.3)] , in combination wit...
Mycophenolic Acid (MPA) 霉酚酸;Immunosuppressive Drug 免疫抑制剂;Inosine monophosphatase dehydrogenase 次黄嘌呤单核苷酸脱氢酶;IMPDH Inhibitor; Mycophenolate mofetil 吗替麦考酚酯;CAS NO:128794-94-5; 产品信息 产品名称 产品编号 CAS NO. 规格 价格(元) ...