Comparative incorporation experiments with (1′-14C)-orsellinic acid (2) and (1′-14C)-4,6-dihydroxy-2,3-dimethylbenzoic acid (3) suggest that only the latter compound is a specific precursor of mycophenolic acid; the implication of this result in terms of the early stages of the ...
Compartmentalized biosynthesis of mycophenolic acid. Credit: ZHANG Wei and LI Shengying Mycophenolic acid (MPA), discovered in 1893, was the first natural antibiotic to be isolated and crystallized in human history. Today, this fungal metabolite has been developed into multiple first-line immunosuppress...
Compartmentalized biosynthesis of mycophenolic acid. Proc. Natl Acad. Sci. USA 116, 13305–13310 (2019). Article CAS PubMed PubMed Central Google Scholar Yang, X. et al. Cyclosporine biosynthesis in Tolypocladium inflatum benefits fungal adaptation to the environment. mBio 9, e01211-18 (2018)...
The true litmus test for the importance of these findings will be when studies are conducted examining levels of these proteins in more human tumor types driven by MYC overexpression (eg. Burkitt's lymphoma, breast cancer, colon cancer). Certainly drugs like mycophenolic acid, which inhibit ...
The suggestion involved active methionine forMe, and a source, then unknown, of terpenoid cations. The first support for the suggestions was provided by examination of mycophenolic acid (3) (Ref. 13). The degraded terpene side-chain was shown to come from mevalenie acid, and-the nuclear Me...
A similar modification has been observed in the biosynthetic pathway for production of mycophenolic acid (Regueira et al., 2011). Here it was proposed to occur by oxidative cleavage between C-4 and C-5 of the sesquiterpene chain. Alternatively, it could occur by terminal oxidation of a ...
MpaG′ catalyzes the methylation of demethylmycophenolic acid (DMMPA, 6) to form 1. It also showed significant substrate flexibility by methylating two structural derivatives of 6 prepared by organic synthesis.doi:10.1002/cbic.201402600Wei Zhang...
Mycophenolic acid (MPA,1) and its derivatives are first-line immunosuppressants used in organ transplantation and for treating autoimmune diseases.Despite chemical synthetic achievements,the biosynthetic formation of a seven-carbon carboxylic acid pharmacophore side chain of 1,especially the processes ...
It was established that the introduction of 0.015% sodium nitrite into the medium resulted in 1.3- and 1.4-fold reductions of the production of citrinin and mycophenolic acid, respectively, while the production of cyclopiazonic acid did not change in comparison with the control. The introduction of...
The crystal structure reveals the position of the IMPDH moveable flap and catalytic arginine in the open conformation for the first time, plus unique, exploitable differences in the highly conserved active site. Treatment with mycophenolic acid led to significantly increased survival times in a ...