The typical pathological feature of pancreatic ductal adenocarcinoma (PDAC) is a significant increase in stromal reaction, leading to a hypoxic and poorly vascularized tumor microenvironment. Tumor cells undergo metabolic reprogramming, such as the Warbu
The proto-oncogene c-Myc encodes a short-lived protein c-Myc that regulates various cellular processes including cell growth, differentiation and apoptosis. Degradation of c-Myc is catalyzed by the proteasome and requires phosphorylation of Thr-58 for ubiquitination by E3 ubiquitin ligase, Fbxw7/ ...
3D). To investigate whether UBTD1 regulates c-Myc protein depending on its ubiquitin domain, we investigated the effect of mutated-UBTD1 that removed ubiquitin domain (Mut) on c-Myc protein, which had been demonstrated to be loss of function in our previous study [10]. We discovered that...
Here we report that the degradation of the myc proteins in cells is inhibited by lactacystin and MG132, two inhibitors of the 20S proteasome. Inhibition is accompanied by accumulation of myc-ubiquitin conjugates. Dissection of the ancillary proteins involved revealed that the high-risk human ...
Ubiquitin-specific protease 7 maintains c-Myc stability to support pancreatic cancer glycolysis and tumor growth 来自 Springer 喜欢 0 阅读量: 4 作者:J Gu,X Xiao,C Zou,Y Mao,C Jin,D Fu,R Li,H Li 摘要: The typical pathological feature of pancreatic ductal adenocarcinoma (PDAC) is a ...
For further investigation, we targeted the IFN signaling pathway-mediating protein, N-Myc(and STAT) interactor(Nmi). Its interaction with P6 was confirmed within cells. The results showed that P6 can promote the ubiquitin-dependent proteosomal degradation of Nmi. This study revealed a new ...
Novel c-Myc-Targeting Compound N, N-Bis (5-Ethyl-2-Hydroxybenzyl) Methylamine for Mediated c-Myc Ubiquitin-Proteasomal Degradation in Lung Cancer Cells.doi:10.1124/MOL.120.119719Nicharat SriratanasakKorrakod PetsriApirat LaobutheeWorawat Wattanathana...
A complex of the ubiquitin ligase TRIM32 and the deubiquitinase USP7 balances the level of c-Myc ubiquitination and thereby determines neural stem cell fate specification Sarah Nicklas, Anna-Lena Hillje, Satoshi Okawa, Ina-Maria Rudolph, Franziska Melanie Collmann, Thea van Wuellen, Anton...
Development of the nervous system requires that timely withdrawal from the cell cycle be coupled with initiation of differentiation. Ubiquitin-mediated degradation of the N-Myc oncoprotein in neural stem/progenitor cells is thought to trigger the arrest
For further investigation, we targeted the IFN signaling pathway-mediating protein, N-Myc(and STAT) interactor(Nmi). Its interaction with P6 was confirmed within cells. The results showed that P6 can promote the ubiquitin-dependent proteosomal degradation of Nmi. This study revealed a new ...