pCMV-Myc-ubiquitin(K48RK63R)pCMV-Myc-ubiquitin(K48RK63R) 上海海吉浩格生物科技有限公司 http://hedgehogbio.com测序及更多信息: 点击联系我们QQ:1822235623 微信:1822235623,17031145927 HH-Z-271 pCAGGS HH-Z-270 pECFP-C1 HH-QT-035 pCMV-CircRNA-coGFP-puro环状RNA表达载体 HH-Z-268 piggyBac-EF1a-...
The ubiquitin proteasome system-implications for cell cycle control and the targeted treatment of cance[r J]. Biochim Biophys Acta, 2014, 1843(1): 150-62. [8] Nakayama KI, Nakayama K. Regulation of the cell cycle by SCF- type ubiquitin ligase[s J]. Semin Cell Dev Biol, 2005, 16(3)...
Over a dozen of ubiquitin ligases have been found to ubiquitinate MYC whereas a number of deubiquitinating enzymes counteract this process. Recent studies show that SUMOylation and deSUMOylation can also regulate MYC protein stability and activity. Interestingly, evidence suggests an intriguing ...
Adhikary S, Marinoni F, Hock A, Hulleman E, Popov N, Beier R, Bernard S, Quarto M, Capra M, Goettig S et al (2005) The ubiquitin ligase HectH9 regulates transcriptional activation by Myc and is essential for tumor cell proliferation. Cell 123:409–421 Article CAS PubMed Google Scholar...
近日,西班牙国家生物技术中心Roberto Solano研究组在PNAS在线发表了一篇题为CUL3BPM E3 ubiquitin ligases regulate MYC2, MYC3 and MYC4 stability and JA responses的研究论文。该研究揭示了JA信号途径新的调控机制,即CUL3BPME3泛素连接酶调节MYC2和MYC3及MYC4蛋白稳定性,从而调控JA信号途径。
USPs, ubiquitin-specific proteases; UCHs, ubiquitin C-terminal hydrolases; OTUs, ovarian tumor proteases; MJDs, Machado-Joseph disease protein domain proteases; JAMM, JAB1/MPN/MOV34 family. B Volcano plot of glycolysis-related DUBs, as identified by gene set enrichment analysis. ES, enrichment ...
Ubiquitin-specific protease 28 deubiquitinates TCF7L2 to govern the action of the Wnt signaling pathway in hepatic carcinoma. Cancer Sci. 2022;113:3463–75. Article CAS PubMed PubMed Central Google Scholar Sun W, Shen J, Liu J, Han K, Liang L, Gao Y. Gene Signature and Prognostic ...
E. FBW7 ubiquitin ligase: a tumour suppressor at the crossroads of cell division, growth and differentiation. Nature Rev. Cancer 8, 83–93 (2008). Article CAS Google Scholar Sears, R. C. The life cycle of C-myc: from synthesis to degradation. Cell Cycle 3, 1133–1137 (2004). ...
Mutant ubiquitin found in neurodegenerative disorders is a ubiquitin fusion degradation substrate that blocks proteasomal degradation Loss of neurons in neurodegenerative diseases is usually preceded by the accumulation of protein deposits that contain components of the ubiquitin/proteaso... Lindsten,K. - ...
The ubiquitin ligase FBXW7 modulates leukemia-initiating cell activity by regulating MYC stability. Cell 153, 1552–1566 (2013). CAS PubMed PubMed Central Google Scholar Yeh, C.-H., Bellon, M. & Nicot, C. FBXW7: a critical tumor suppressor of human cancers. Mol. Cancer 17, 115 (...