关键词:胡桃醌;宫颈癌;HeLa;c-Myc;泛素化 Abstract:Objective To observe the expression of c-Myc protein in cervical cancer HeLa cells and explore the effect of juglone on the proliferation and apoptosis of HeLa cells by affecting c-Myc ubiquitination. Methods HeLa cells treated with different conce...
Ubiquitination plays a key role in regulating multiple oncoproteins, including those of the Myc-family. A recent Cell paper by Adhikary et al reports that a novel E3 ligase, HectH9, mediates site-specific ubiquitination of Myc and thereby fosters a switch from repression to transcriptional ...
Interestingly, evidence suggests an intriguing crosstalk between MYC ubiquitination and SUMOylation. Deregulation of the MYC ubiquitination-SUMOylation regulatory network may contribute to tumorigenesis. This review is intended to provide the current understanding of the complex regulation of the MYC biology...
Authors - Tejas R Karhadkar View Article CoIP PLoS One The interplay of Rac1 activity, ubiquitination and GDI binding and its consequences for endothelial cell spreading. Authors - Jisca Majolée View Article See more citationsProteintech North America (HQ) Proteintech Group, Inc 5500 Pearl Street...
Ubiquitination of Myc: Proteasomal Degradation and Beyond The level of Myc proteins is a critical determinant of cellular proliferation and apoptosis. Ubiquitination of Myc plays a key role in controlling protein levels by stimulating proteasomal degradation of the protein. Some experimen... J Müller,...
Ubiquitinated by the SCF(FBXW7) complex when phosphorylated at Thr-58 and Ser-62, leading to its degradation by the proteasome. In the nucleoplasm, ubiquitination is counteracted by USP28, which interacts with isoform 1 of FBXW7 (FBW7alpha), leading to its deubiquitination and preventing degra...
Hepatitis B virus X protein enhances Myc stability by inhibiting SCF(Skp2) ubiquitin E3 ligase-mediated Myc ubiquitination and contributes to oncogenesis. Oncogene. 2016;35:1857–67. Article CAS PubMed Google Scholar Shukla SK, Kumar V. Hepatitis B virus X protein and c-Myc cooperate in the...
26,36 MBIIIb encompasses a 10-amino-acid segment that is part of a PEST domain rich in proline, glutamic acid, threonine and serine residues that expands from positions 226-270 and is involved in the regulation of MYC stability but not in ubiquitination.37 MBIV domain may only be required...
NLRP14 Safeguards Calcium Homeostasis via Regulating the K27 Ubiquitination of Nclx in Oocyte-to-Embryo Transition Authors - Tie-Gang Meng View Article human WB Int J Biol Sci CTSG Suppresses Colorectal Cancer Progression through Negative Regulation of Akt/mTOR/Bcl2 Signaling Pathway Authors - Shixin...
HMGA1 stimulates MYH9- dependent ubiquitination of GSK-3β via PI3K/Akt/c-Jun signaling to promote malignant progression and chemoresistance in gliomas [J]. Cell Death Dis, 2021, 12(12): 1147. [46]Liu YY, Jiang QP, Liu X, et al. Cinobufotalin powerfully reversed EBV-miR-BART22-...