Single MVA-SARS-2-ST/N vaccination in K18-hACE2 mice induced robust protection against lethal respiratory SARS-CoV-2 challenge infection 28 days later. The protective outcome of MVA-SARS-2-ST/N vaccination correlated with the activation of SARS-CoV-2-neutralizing antibodies (nA...
Despite this, our data clearly showed that MVA-SARS-2-ST induced superior humoral immune responses relative to MVA-SARS-2-S after both immunization schedules.doi:10.3390/v15051180Kalodimou, GeorgiaJany, SylviaFreudenstein, AstridSchwarz, Jan Hendrik...
One vaccine, MVA-SARS-2-S, expressed the native form of the S protein [19], whereas the second vaccine, MVA-SARS-2-ST, expressed a modified prefusion stabilized form of the S protein [20]. Both vaccines were highly immunogenic when tested in a preclinical mouse model, inducing strong ...