Multiple system atrophyPrognosisMultiple system atrophy (MSA) is a neurodegenerative disorder characterized by a combination of autonomic failure plus cerebellar syndrome and/or parkinsonism. Dysphagia is a frequent and disabling symptom in MSA and its occurrence within 5 years of motor onset is an ...
Multiple System Atrophy (MSA) and Parkinson's diseases (PD) are elite members of the α-synucleinopathy organization. Aberrant accumulations of the protein α-synuclein characterize them. A plethora of evidence indicates the involvement of these rogue inclusions in a cascade of events that disturb ...
//doi.org/10.1186/s40478-019-0730-6 REVIEW Open Access Understanding the pathogenesis of multiple system atrophy: state of the art and future perspectives Giacomo Monzio Compagnoni and Alessio Di Fonzo* Abstract Multiple System Atrophy (MSA) is a severe neurodegenerative disease clinically ...
This is not surprising given that gliosis is a pathological feature of these disease processes. Degenerations of grey matter may simulate primary progressive multiple sclerosis. Autosomal dominant cerebellar ataxia is distinguished by the presence of severe cerebellar atrophy and a paucity of white ...
Conclusions Magnetic resonance imaging has become a powerful tool for the study of MS, with practical applications in diagnosis and prediction of prognosis and with research applications in the study of MS natural history. In addition, MRI is now included as an adjunctive measure in clinical trials...
Multiple system atrophy (MSA) is an adult-onset, sporadic, progressive neurodegenerative disease caused by oligodendroglial aggregation of α-synuclein affecting predominantly the nigrostriatal, olivo-ponto-cerebellar, and autonomic systems [1,2,3,4]. MSA is characterized by varying severity of parkinso...
The lesion-led subtypes had the worst prognosis in terms of accumulation of pathology (faster lesion accumulation) and disability progression. Disease duration, both in the training dataset (9.09 years) and the validation dataset (11.63 years), was the highest in the lesion-led subtype. We postul...
Our incomplete understanding of the causes and pathways involved in the onset and progression of multiple sclerosis (MS) limits our ability to effectively treat this complex neurological disease. Recent studies explore the role of immune cells at differe
1 Multiple organ dysfunction syndrome is defined as a clinical syndrome characterized by development of progressive and potentially reversible dysfunction in two or more organs or organ systems. From: Trends in Anaesthesia and Critical Care, 2013 ...
Establishing the prognosis for multiple sclerosis (MS) early in the disease course is critically important for patients who develop this disease. Potentially, this information could be used to guide the selection of which disease modifying therapy (if any) should be started in which individual and ...