Multiple system atrophy (MSA) is a sporadic, rapidly progressive neurodegenerative disorder characterized clinically by a combination of cerebellar dysfunction or parkinsonism and autonomic failure. The histopathological hallmark of MSA is the presence of glial cytoplasmic inclusions composed predominantly of ...
Multiple system atrophy (MSA) is a rare neurodegenerative disease that is characterized by neuronal loss and gliosis in multiple areas of the central nervous system including striatonigral, olivopontocerebellar and central autonomic structures. Oligodend
Ozawa, T.et al. The spectrum of pathological involvement of the striatonigral and olivopontocerebellar systems in multiple system atrophy: clinicopathological correlations.Brain127, 2657–2671 (2004). ArticlePubMedGoogle Scholar Benarroch, E. E., Schmeichel, A. M., Sandroni, P., Low, P. A....
//doi.org/10.1186/s40478-019-0730-6 REVIEW Open Access Understanding the pathogenesis of multiple system atrophy: state of the art and future perspectives Giacomo Monzio Compagnoni and Alessio Di Fonzo* Abstract Multiple System Atrophy (MSA) is a severe neurodegenerative disease clinically ...
2, Glenda M Halliday1,2 and Woojin Scott Kim1,2* Abstract Multiple system atrophy (MSA) is a progressive neurodegenerative disease characterized by the accumulation of α-synuclein protein in the cytoplasm of oligodendrocytes, the myelin-producing support cells of the central nervous system (CNS)....
Parkinson's disease (PD) and multiple system atrophy (MSA) are distinct clinical syndromes characterized by the pathological accumulation of α-synuclein (α-syn) protein fibrils in neurons and glial cells. These disorders and other neurodegenerative diseases may progress via prion-like mechanisms. The...
Multiple System Atrophy (MSA) and Parkinson's diseases (PD) are elite members of the α-synucleinopathy organization. Aberrant accumulations of the protein α-synuclein characterize them. A plethora of evidence indicates the involvement of these rogue inclusions in a cascade of events that disturb ...
摘要: (1999) Separating the primary autonomic failure syndromes, multiple system atrophy, and pure autonomic failure from Parkinson's disease. In: , (ed.) (353 - 361). Lippincott Williams and Wilkins: Philadelphia.DOI: http://discovery.ucl.ac.uk/139825/ 被引量: 46 ...
OBJECTIVES: The majority of patients with diffuse Lewy body disease have cognitive or psychiatric manifestations as part of their initial presentation. A sizable minority present with parkinsonian features alone. Autonomic features may also occur, typically after the development of cognitive changes. We ...
Multiple System Atrophy (MSA) and Parkinson’s diseases (PD) are elite members of the α-synucleinopathy organization. Aberrant accumulations of t