Multiple system atrophy (MSA) is a neurodegenerative disease with diverse clinical manifestations, including parkinsonism, cerebellar syndrome, and autonomic failure. Pathologically, MSA is characterized by glial cytoplasmic inclusions in oligodendrocyte
Moreover, [156] reports articulatory differences in progressive supranuclear palsy, multiple system atrophy, and PD, especially when analyzing VOT. Moreover, there are other challenges that machine learning approaches have to overcome to derive into more reliable and causally robust diagnosis systems [...
Patients with multiple system atrophy (MSA) frequently experience dysphagia but only few studies analyzed its characteristics. The aim of this study was to
people with MS can die early frompneumoniaor other infections related to their disease, most people die from other ailments. Overall, the life expectancy of someone with MS is only about 5% less than that of a normal healthy adult.
This silent disease activity can occur in both white and gray matter and is associated with cerebral atrophy, which in most patients is evident in volumetric studies even at diagnosis. Natural history data indicate that approximately 50% of patients with RRMS convert to a secondary progressive ...
Optical coherence tomography (OCT), a test used to detect changes in the retina, which could warn of brain atrophy. Multiple sclerosis vs. myasthenia gravis MS andmyasthenia gravis(MG) are both disorders of the immune system that cause weakness. MS impacts the central nervous system and more ...
(percentage of brain volume changes [PBVC]) were significantly reduced in patients treated with clad- ribine tablets 3.5 mg/kg versus placebo (0.77% vs. 0.95%; p = 0.02), based on PBVC over months 6–24, to avoid the confounding influence of pseudoatrophy in the first 6 ...
(Jacobson et al.1990). MRI has demonstrated demyelinating lesions in both the white matter and the periventricular regions of HAM/TSP brains and swelling or atrophy in the spinal cord. Although the distinct plaques characteristic of MS are not observed in HAM/TSP, loss of myelin with some ...
De Stefano N, Stromillo ML, Giorgio A, Bartolozzi ML, Battaglini M, Baldini M, Portaccio E, Amato MP, Sormani MP (2016) Establishing pathological cut-offs of brain atrophy rates in multiple sclerosis. J Neurol Neurosurg Psychiatry 87:93–99 Article PubMed Google Scholar Dean G, Elian M...
(Jacobson et al.1990). MRI has demonstrated demyelinating lesions in both the white matter and the periventricular regions of HAM/TSP brains and swelling or atrophy in the spinal cord. Although the distinct plaques characteristic of MS are not observed in HAM/TSP, loss of myelin with some ...