Moreover, [156] reports articulatory differences in progressive supranuclear palsy, multiple system atrophy, and PD, especially when analyzing VOT. Moreover, there are other challenges that machine learning app
Most commonly, multiple system atrophy begins early in the sixth decade of life, progresses more rapidly than Parkinson's disease, and has a lower life expectancy (median survival = 9.3 years). No case of multiple system atrophy has been reported before the age of 30. Parkinsonism occurs in ...
This silent disease activity can occur in both white and gray matter and is associated with cerebral atrophy, which in most patients is evident in volumetric studies even at diagnosis. Natural history data indicate that approximately 50% of patients with RRMS convert to a secondary progressive ...
De Stefano N, Stromillo ML, Giorgio A, Bartolozzi ML, Battaglini M, Baldini M, Portaccio E, Amato MP, Sormani MP (2016) Establishing pathological cut-offs of brain atrophy rates in multiple sclerosis. J Neurol Neurosurg Psychiatry 87:93–99 Article PubMed Google Scholar Dean G, Elian M...
Also, an additional point to acknowledge is that age-related diseases like MS often present within an environment of acquired senescent cells, referred to as primary, which have accumulated as a result of normal tissue atrophy. Tissue resilience to stressful insults from an ongoing condition is ...
Early-life exposure to POPs harms male reproduction across multiple generations. FA supplementation partly mitigated the impact of POPs. The two-cell embryo transcriptome is susceptible to paternal environment and could be the foundation for later pregnancy outcomes....
This silent disease activity can occur in both white and gray matter and is associated with cerebral atrophy, which in most patients is evident in volumetric studies even at diagnosis. Natural history data indicate that approximately 50% of patients with RRMS convert to a secondary progressive ...
Status Scale (EDSS) (Kurtzke, 1983), which assesses eight functional systems including pyramidal, sensory, cerebellar, visual, bladder/bowel,brainstem, cerebral/mental, and “other.” EDSS also provides information about a patient’s ambulation ability. An EDSS score of 6.0 or higher indicates ...
Microfluidics platforms have thus revolutionized novel capabilities in addressing the requirements of point-of-care diagnostics enabling miniaturization by integrating multiple laboratory functions into a single chip resulting in “one flow - one solution” systems. Hence, the precision and early diagnoses ...
Additionally, the depletion of neurological reserve means that fewer resources remain to combat the cognitive and physical effects of normal age-related brain atrophy (Schwartz et al., 2013). Effective DMT and lifestyle interventions must, therefore, be initiated as soon as the disease is diagnosed...