Evidence for a missed signal to the CD8+cells in CSF of Multiple Sclerosis patients CD8+ T cells may play an important role in multiple sclerosis (MS). Whether these cells would be involved in early stages of MS is unclear. We enrolled 52 ... M Saresella,A Grope,L Speciale,... 被引...
CSF T-cell subsets in multiple sclerosis: relationship to cerebrospinal fluid myelin basic protein and clinical activity. J. Neurol. 236, 336-339.CSF T-cell subsets in multiple sclerosis: Relationship to cerebrospinal fluid myelin basic protein and clinical activity[J] . A. Salmaggi,L. Mantia,...
Immunological involvement in multiple sclerosis (MS) has been clearly established. In particular, the presence of T cells infiltrating MS brain parenchima has been reported,1–3 suggesting a process of immune-mediated damage. However, two major questions are still unresolved: first, if the reported...
Immunoglobulins in Multiple Sclerosis and Infections of the Nervous System Increased relative cerebrospinal fluid (CSF) concentrations of immunoglobulin G, immunoglobulin A, and immunoglobulin M were found in 73%, 9%, and 0% of 64... H Link,R Muller - 《Archives of Neurology》 被引量: 513...
Multiple sclerosis (MS) is the most common chronic inflammatory, demyelinating and neurodegenerative disease of the central nervous system in young adults. This disorder is a heterogeneous, multifactorial, immune-mediated disease that is influenced by bo
Body weight and height of patients with relapsing-remitting multiple sclerosis (RRMS) or clinically isolated syndrome suggesting MS (CIS) in the age range 18 to 60 years (154 males and 315 females) were compared with those of subjects (146 males and 212 females) free of any major neurological...
Our incomplete understanding of the causes and pathways involved in the onset and progression of multiple sclerosis (MS) limits our ability to effectively treat this complex neurological disease. Recent studies explore the role of immune cells at differe
2) multiple sclerosis [脑脊髓]多发性硬化3) spinal cord of multiple sclerosis 脊髓型多发性硬化 1. MRI diagnostic value in the spinal cord of multiple sclerosis; 脊髓型多发性硬化的MRI诊断价值 更多例句>> 4) spinal cord multiple sclerosis 多发性硬化脊髓型...
autoreactive T cells will go through theblood brain barrier, or the blood-CSF barrier, and enter the CNS initiating an inflammatory attack against myelin sheaths. T cell invasion in CNS is associated with the formation of plaques in the brain white matter of multiple sclerosis patients (Kivisakk...
The aberrant expression of B7 costimulatory molecules is involved in the pathogenesis of autoimmune diseases and overexpression of B7-1 was found in inflammatory multiple sclerosis (MS) lesions. We here report that costimulatory molecules B7-1 and B7-2 are expressed on cerebrospinal fluid (CSF) mono...