Classification models based on the biomarker panel could identify 70% of the RRMS and 80% of the SPMS patients correctly. Further evaluation was conducted in a pilot study of CSF from RRMS patients (n = 36), before and after treatment with natalizumab.Jan...
CSF IgG (Immunoglobulin G)—increased in some conditions, such as multiple sclerosis, herpes encephalitis, connective tissue diseases Myelin basic protein—seen when the covering of nerves (myelin) breaks down, such as with multiple sclerosis CSF lactate—often used to distinguish between viral and ...
GM-CSF is poorly expressed in the adult brain [67, 68], but is upregulated in some inflammatory contexts such as multiple sclerosis [69, 70], in which it is thought to exert its mitogenic effect on microglia. Interestingly, increased GM-CSF expression has been previously detected in the ...
Although oxylipins are involved in inflammation, data on these lipid mediators in multiple sclerosis are sparse. In this study, a panel of oxylipins were a... Hakansson, IreneGouveia-Figueira, SandraErnerudh, JanVrethem, MagnusGhafouri, NazdarGhafouri, BijarNording, Malin - 《Prostaglandins & ...
YKL-40 can be detected in cerebrospinal fluid (CSF) and the levels are increased in preclinical and prodromal AD, as well as in other neurodegenerative conditions, such as Frontotemporal Lobar Degeneration (FTLD), Amyotrophic Lateral Sclerosis (ALS) or Multiple Sclerosis (MS)7,8,9,10. Other ...
panel for disease separation. The optimal number of features that maximized the classifier performance was 18, 90, and 70 for the nonlinear and linear support vector machine and random forest, respectively. Performance measures of the different models are compared in Fig.6B. Using the area under ...
Author links open overlay panelJan Knoop a, Anita Gavrisan a, Denise Kuehn b, Julia Reinhardt b, Melanie Heinrich a, Markus Hippich a, Anne Eugster b, Christian Ockert c, Anette-Gabriele Ziegler a d e, Ezio Bonifacio b d eShow more ...
Excess of unlabeled GM-CSF (bottom panel) competed for PE-GM binding. [0024] Figure 3 demonstrates secretion of antigen-binding IgG by class-switched hybridoma cells. Hybridoma E5 cells (parent) were treated as described in Materials and Methods. Hybridomna clones that had class-switched (...
except in case of early-onset dementia. The AD CSF biomarker panel cannot be used to confirm clinical diagnosis of non-AD dementias, but should be used to confirm or exclude the diagnosis of AD. The AD CSF biomarkers are of great help to select subjects for clinical trials with potentially...
f, Representative image of panel e. Scale bar, 70 μm. g, Neuronal Srf intensity in CA1 in aged mice following YM-CSF infusion. (n = 4; two-sided t-test; mean ± s.e.m). h, Representative image of panel g. Scale bar, 70 μm. Source Data...