multiple sclerosisproteomicsBackground and purpose: In recent years, different approaches have been used to investigate changes of cerebrospinal fluid (CSF) proteome in patients affected by multiple sclerosis (MS) with the aim to identify protein markers with potential diagnostic or prognostic value....
- 《Multiple Sclerosis》 被引量: 1116发表: 1999年 Antibodies produced by clonally expanded plasma cells in multiple sclerosis cerebrospinal fluid The oligoclonal B-cell response in MS cerebrospinal fluid is not targeted to the well-characterized myelin antigens myelin basic protein, proteolipid prote....
Multiple sclerosis (MS) is a neurodegenerative disease associated with inflammatory demyelination and astroglial activation, with neuronal and axonal damage as the leading factors of disability. We aimed to perform a meta-analysis to determine changes in CSF levels of neuronal and glial biomarkers, incl...
Arnason. Multiple sclerosis: activated cells in cerebrospinal fluid in acute exacerbations. Ann.Neurol., 18:722–725 (1985). Article Google Scholar W. E. J. Weber, W.A. Buurman, Myelin basic protein-specific CD4+ cytolitic T-lymphocyte clones isolated from multiple sclerosis patients, Human...
CSF in Multiple Sclerosis -Slightly elevated WBC count -slightly increased total protein (IgG values increase due to intrathecal production of this protein fraction) LP results of Tumor in CNS *opening pressure is typically increased (DANGER LP at this time could lead to herniation of brain through...
CEREBROSPINAL FLUID (CSF) PROTEIN PATTERNS DETERMINED BY ISOELECTRIC FOCUSING IN MULTIPLE SCLEROSIS B.Perthen and W.Müller-Beißenhirtz Department of Clinical Chemistry,Bürgerhospital, D-7000 Stuttgart 1, F.R. of Germany Introduction Unique fractions or groups of fractions were demonstrated by isoe...
CSF levels of neurofilament light and glial fibrillary acidic protein may have prognostic value in multiple sclerosis. N Norgren,P Sundstrom,A Svenningsson,... - 《Neurology》 被引量: 267发表: 2004年 -acetylaspartate and neurofilaments in multiple sclerosis OBJECTIVE: Axonal degeneration is the like...
The two chemokines, monocyte chemoattractant protein (MCP)-1 and γ-interferon inducible protein (IP)-10, are thought to be involved in the pathogenesis of multiple sclerosis (MS). We measured MCP-1 and IP-10 levels in serum and CSF samples from 38 acute and 25 stable MS patients and fro...
The monocyte chemoattractant protein-1 (MCP-1) functions to recruit monocytes and macrophages to areas of inflammation and is a prototypic chemokine subjec... KJM Boss - 《Molecular Immunology》 被引量: 149发表: 2000年 MicroRNA modulation in complex regional pain syndrome Background Aberrant expres...
In CSF of the patients with the first relapse the level of t-tau was significantly increased whilst the level of p-tau was not elevated. 展开 关键词: Keywords: Multiple sclerosis, tau protein, phosphotau protein DOI: 10.1007/s00702-005-0327-z ...