Light chain predominant multiple myelomaMASS-FIX/MALDIMinimal residual diseaseMonoclonal light chainsMultiple myelomaSerum free light chainsNeoplastic monoclonal gammopathies are frequently associated with production of excess free monoclonal light chains. A sensitive method for detecting free monoclonal light ...
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Light chainproteinuria The classic laboratory finding in patients with multiple myeloma is hyperglobulinemia, which results from the excessive production of immunoglobulin or an immunoglobulin subunit by the neoplastic cells. This homogeneous protein fraction is often calledparaproteinorM protein. Paraproteins...
Renal impairment (RI) is common in multiple myeloma (MM) and is associated with poor survival. This study reports the associations between renal function and disease characteristics including serum free light chain (FLC) level at diagnosis in patients with MM. Methods Using data from the Medical ...
Bermudo, CGarcia, J LMartin Ruiz, J ADuro Mill�n, RIglesias, M MRomero, F F
clinical case study sharply increased serum free light-chain concentrations after treatment for multiple myeloma case description case K Murata,RJ Clark,KS Lockington,... 被引量: 0发表: 2013年 Sharply Increased Serum Free Light-Chain Concentrations after Treatment for Multiple Myeloma/Commentary/...
After bone marrow examination, the diagnosis was stage IIA λ light chain multiple myeloma. The patient started bortezomib, melphalan and prednisone treatment. In the following days, λ FLC concentrations still remained elevated indicating therapy failure. A week later, the patient became anuric and ...
free light chain ratioprognosisThe prognostic value of baseline serum free light chain ratio (sFLCR) was investigated in 94 multiple myeloma (MM) patients. sFLCR was calculated as κ / λ or λ / κ , depending on the patients' dominating monoclonal light chain. Median baseline sFLCR was 3...
Guidelines for monitoring light chain multiple myeloma (LCMM) patients currently rely on measurements of the monoclonal protein in urine (Bence Jones proteinuria). However, the presence of light chains in the urine is highly influenced by the individual free light chain, production rate and renal fu...
Case report: Shift in secretion from intact immunoglobulin to free light chains in multiple myeloma at relapse: early detection by free light chain assayGraubaum, KHeymann, G AHunger, TOstapowicz, B