8047#Background:In 2014, the definition of multiple myeloma was updated to include serum free light chain (FLC) ratio ≥100 as a myeloma defining biomarker, based on retrospective data indicating a 2-year progression rate of 80% and a median time to progression (TTP) of 12 months associated...
free light chain ratioprognosisThe prognostic value of baseline serum free light chain ratio (sFLCR) was investigated in 94 multiple myeloma (MM) patients. sFLCR was calculated as κ / λ or λ / κ , depending on the patients' dominating monoclonal light chain. Median baseline sFLCR was 3...
We hypothesize that SMM is a clinical entity comprised of both premalignant, high-risk MGUS and early multiple myeloma in transition to malignant disease, which may be differentiated with the use of the serum FLC (FLC) ratio. Methods: This was a retrospective analysis of 586 patients with ...
We hypothesize that SMM is a clinical entity comprised of both premalignant, high-risk MGUS and early multiple myeloma in transition to malignant disease, which may be differentiated with the use of the serum FLC (FLC) ratio. Methods This was a retrospective analysis of 586 patients with newly...
Quantitative measurement of serum free light chains (S.FLC) has now been adopted into screening algorithms for multiple myeloma (MM). The assay indicates monoclonal free light chain production by the presence of abnormal kappa or lambda free light chain ratio (reference range 0.26-1.65). We repor...
Prognostic value of serum free light chain ratio at diagnosis in multiple myeloma. Br J Haematol. 2007;137(3):240–3. Article CAS PubMed Google Scholar Hutchison CA, Bladé J, Cockwell P, Cook M, Drayson M, Fermand JP, et al. Novel approaches for reducing free light chains in ...
Bermudo, CGarcia, J LMartin Ruiz, J ADuro Mill�n, RIglesias, M MRomero, F F
There are two types of immunoglobulin light chain produced in humans, designated kappa (κ) and lambda (λ). The quantification of serum FLC is used as an aid in the diagnosis and monitoring patients with Multiple Myeloma. Ratio FLC value (kappa FLC/lambda FLC) compared to reference ranges ...
Evaluating serum-free light chain ratio as a biomarker for multiple myeloma. 8047#Background:In 2014, the definition of multiple myeloma was updated to include serum free light chain (FLC) ratio ≥100 as a myeloma defining biomarker... T Akhlaghi,K Maclachlan,N Korde,... - 《Journal of Cl...
clinical case study sharply increased serum free light-chain concentrations after treatment for multiple myeloma case description case K Murata,RJ Clark,KS Lockington,... 被引量: 0发表: 2013年 Sharply Increased Serum Free Light-Chain Concentrations after Treatment for Multiple Myeloma/Commentary/...