This case report describes a rare and interesting case of a patient with multiple myeloma complicated with light chain (LC) cast nephropathy and focal amyloidosis. The patient presented with acute kidney injury, anaemia and bone lesions. The diagnosis was confirmed by bone marrow biopsy, serum an...
International Myeloma Working Group guidelines for serum-free light chain analysis in multiple myeloma and related disorders oligosecretory PCD, including AL, oligosecretory myeloma and nearly two-thirds of patients who had previously been deemed to have non-secretory myeloma. In... A Dispenzieri,R...
Amyloidosis is a rare disease in which amyloid fibrils compromise organ function and lead to death. Systemic immunoglobulin light-chain amyloidosis, usuall... Raymond,L.,Comenzo - 《Clinical Lymphoma Myeloma & Leukemia》 被引量: 29发表: 2008年 加载更多来源...
Multiple Myeloma is a plasma cell proliferative disorder that commonly involves the kidney. Renal impairment is a serious complication during the course of the disease that is associated with increased morbidity and mortality. Light chain cast nephropathy is the predominant pattern of renal injury in M...
(LHCDD). LCDD is the most common of the MIDDs, and the majority of cases occur in the setting ofmultiple myelomaor nonmyeloma plasma cell clones.31Onkidney biopsy,immunofluorescencemicroscopy shows staining for kappa, or less commonly lambda,light chain, without staining forIg heavy chain. ...
4) Multiple Myeloma(MM) 多发性骨髓瘤 1. Objective:To investigate the application of immunoglobulin heavy chain(IgH) gene rearrangement in the diagnosis and therapy of multiple myeloma(MM). 目的:探讨免疫球蛋白重链(IgH)基因重排在多发性骨髓瘤(MM)患者治疗过程中监测的临床意义。 2. Objective To ...
Light chain myeloma with meningeal and pleural involvement A 76-year-old woman with newly diagnosed lambda light chain myeloma was found to have involvement of the pleura and meninges. Direct immunofluorescence demonstrated the monoclonal nature of plasma cells found in the pleural fluid; morpho... ...
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International Myeloma Working Group guidelines for serum-free light chain analysis in multiple myeloma and related disorders The serum immunoglobulin-free light chain (FLC) assay measures levels of free kappa and lambda immunoglobulin light chains. There are three major indicatio... A Dispenzieri,R ...
Genome-wide association study of immunoglobulin light chain amyloidosis in three patient cohorts: comparison with myeloma. Leukemia. 2017;31:1735–42. Article Google Scholar Kaufman GP, Schrier SL, Lafayette RA, Arai S, Witteles RM, Liedtke M. Daratumumab yields rapid and deep hematologic ...