A diagnosis of light-chain multiple myeloma was made in an 11-year-old male American Shorthair cat. The cat showed atypical plasma cell infiltration in the bone marrow, biclonal gammopathy caused by polymerization of myeloma protein (M-protein), and Bence-Jones proteinuria. The M-protein in ...
4) Multiple Myeloma(MM) 多发性骨髓瘤 1. Objective:To investigate the application of immunoglobulin heavy chain(IgH) gene rearrangement in the diagnosis and therapy of multiple myeloma(MM). 目的:探讨免疫球蛋白重链(IgH)基因重排在多发性骨髓瘤(MM)患者治疗过程中监测的临床意义。 2. Objective To ...
Renal impairment (RI) is common in multiple myeloma (MM) and is associated with poor survival. This study reports the associations between renal function and disease characteristics including serum free light chain (FLC) level at diagnosis in patients with MM. Methods Using data from the Medical ...
function and urine volume,urine free light chain detection had good specificity and sensitivity.Conclusion The combined determination of urine κ/λ light chain can early predict and prevent the happening of multiple myeloma,which was convenient,rapid and no hurt and has high clinical diagnosis value...
Serum-free light-chain analysis in diagnosis and management of multiple myeloma and related conditions The introduction of the serum-free light-chain (S-FLC) assay has been a breakthrough in the diagnosis and management of plasma cell dyscrasias, particularl... P Milani,G Palladini,G Merlini -...
Amyloidosis occurred most frequently in patients with IgG myeloma (67%), (OR = 1.98), was more often found in patients with kappa light chain versus lambda, respectively 67% and 33%. The probability of amyloidosis in patients with clinical stage III was 1.5 times higher (p = 0.05) than ...
Pathogenesis and Diagnosis of AL Amyloidosis Freeimmunoglobulin light chainstypically adopt a soluble protein conformation that allows them to circulate in the bloodstream. In the setting of excessive monoclonallight chainproduction, certain light chains will aggregate to form insoluble amyloid fibrils, which...
Multiple Myeloma is a plasma cell proliferative disorder that commonly involves the kidney. Renal impairment is a serious complication during the course of the disease that is associated with increased morbidity and mortality. Light chain cast nephropathy is the predominant pattern of renal injury in ...
Serum free light-chain assay for the detection and monitoring of multiple myeloma and related conditions Diagnosis and monitoring of multiple myeloma (MM) and related conditions are usually carried out by means of serum and urine protein electrophoresis and im... P Tosi,S Tomassetti,A Merli,......
Light chain amyloidosis needs to be considered in the differential diagnosis of patients with nondiabetic nephrotic range proteinuria, unexplained fatigue or heart failure with preserved ejection fraction, a progressive peripheral neuropathy associated with a monoclonal protein, or atypical multiple myeloma. ...