Multiple myelomaSerum free light chainsNeoplastic monoclonal gammopathies are frequently associated with production of excess free monoclonal light chains. A sensitive method for detecting free monoclonal light chains in serum could provide a marker for residual/minimal residual disease and as an adjunct ...
1. Light Chain Myeloma Most people with myeloma make antibodies known as immunoglobulins. If you only make an incomplete immunoglobulin known as light chain antibody, you have light chain myeloma. Only 20% of people with myeloma have this kind. These proteins can collect in the kidneys and dama...
Multiple myeloma (MM) is a hematological malignancy characterized by clonal proliferation of plasma cells. Although therapeutic advances have been made to improve clinical outcomes and to prolong patients’ survival in the past two decades, MM remains largely incurable. Single-cell sequencing (SCS) is...
PB2189 FREE LIGHT CHAINS IN MULTIPLE MYELOMA: IS IT TIME TO EXTEND THEIR APPLICATION?doi:10.1097/01.HS9.0000567236.65953.60Markovic, U.Leotta, V.Giubbolini, R.Romano, A.Del Fabro, V.Di Raimondo, F.Conticello, C.HemaSphere
Different types of myeloma are classified by the type of immunoglobulin produced by the abnormal plasma cells. Immunoglobulins (Ig) are made up of two structural components: light chains and heavy chains and further classified by the type of light (kappa or lambda) or heavy (alpha [IgA], gamm...
Myeloma light chains accumulate in the renal epithelial cells and destroy the entire nephron Clinical signs such as anemia, renal insufficiency, or lytic bone lesions Complications: Pathologic fractures Hypercalcemia Renal failure Recurrent infection Anemia Spinal cord compression (10% of all multiple myel...
Renal impairment (RI) is common in multiple myeloma (MM) and is associated with poor survival. This study reports the associations between renal function and disease characteristics including serum free light chain (FLC) level at diagnosis in patients with MM. Methods Using data from the Medical ...
Biclonal plasma cell myeloma with the simultaneous appearance of both secretory lambda and nonsecretory kappa monoclonal light chains To investigate how capillary electrophoresis (CE) works in oligo-secretory myeloma (OSM), we report a case here of OSM using multiple diagnostic methods in... HJ Gu...
Multiple Myeloma Multiplemyelomais a multifocal malignant proliferation of monoclonal plasma cells that occurs most commonly in men older than 60 years. Diagnosis is confirmed by bone biopsy or by demonstratingBence Jones proteins(free light chains) in urine ormonoclonal gammopathyin serum. Although it...
Reprints and permissions About this article Cite this article Espiño, M., Arteche-López, A., Medina, S.et al.Involved/uninvolved heavy/light chain index can predict progression in transplanted multiple myeloma patients.Bone Marrow Transplant52, 1206–1207 (2017). https://doi.org/10.1038/bmt...