Serum free light chains should be the target of response evaluation in light chain multiple myeloma rather than urinesAccording to the IMWG criteria, evaluation of response in multiple myeloma (MM) is based on the measurement of the monoclonal protein in serum and/or urine. In patients secreting...
serum free light chainsserum protein electrophoresisFor many years, Bence Jones proteinuria has been an important diagnostic marker for multiple myeloma. Relatively new serum tests for free kappa and free lambda light chains of immunoglobulins reflect the production of free light chains more accurately ...
Bermudo, CGarcia, J LMartin Ruiz, J ADuro Mill�n, RIglesias, M MRomero, F F
Renal impairment (RI) is common in multiple myeloma (MM) and is associated with poor survival. This study reports the associations between renal function and disease characteristics including serum free light chain (FLC) level at diagnosis in patients with MM. Methods Using data from the Medical ...
Also Known As: Free Light Chains, SFLC, FLC, Kappa and Lambda Free Light Chains, Quantitative Serum Free Light Chains with Ratio Board Approved At a Glance Why Get Tested? To help detect, diagnose, and monitor plasma cell disorders (dyscrasias) such as multiple myeloma, primary amyloidosis,...
Guidelines for monitoring light chain multiple myeloma (LCMM) patients currently rely on measurements of the monoclonal protein in urine (Bence Jones proteinuria). However, the presence of light chains in the urine is highly influenced by the individual free light chain, production rate and renal fu...
Ressources | Current Status of Detecting Monoclonal Antibodies and Free Light Chains in Serum | Deutschland
Diagnosis and monitoring of multiple myeloma (MM) and related conditions are usually carried out by means of serum and urine protein electrophoresis and immunofixation. In the early 2000s, an assay aimed at evaluating serum free light chains (sFLCs) was made available and subsequently tested in ...
Serum free light chain analysis and urine immunofixation electrophoresis in patients with multiple myeloma. Clin Cancer Res. 2005; 11(24 Pt 1):8706–14. Article CAS PubMed Google Scholar Hill PG, Forsyth JM, Rai B, Mayne S. Serum free light chains: an alternative to the urine Bence ...
Quantitative measurement of serum free light chains (S.FLC) has now been adopted into screening algorithms for multiple myeloma (MM). The assay indicates monoclonal free light chain production by the presence of abnormal kappa or lambda free light chain ratio (reference range 0.26-1.65). We repor...