Definition Multiple myeloma is a malignant plasma cell disorder characterized by accumulation of malignant plasma cells within the bone marrow and the secretion of a monoclonal protein, usually IgG or IgA .DefinitionMultiple myeloma is a malignant plasma cell disorder characterized by accumulation of ...
1. fracture at two or more places in a bone; 2. fracture of several bones occurring simultaneously. Farlex Partner Medical Dictionary © Farlex 2012 multiple fracture Two or more fractures, either:(1) In the same bone; or(2) In different bones, but occurring at the same time or caus...
multiple myeloma, malignant proliferation of cells within the bone marrow that usually occurs during middle age or later and increases in occurrence with age. Myelomas are slightly more common in males than in females and can affect any of the marrow-containing bones, such as the skull, the ...
Multiple myeloma, malignant proliferation of cells within the bone marrow that usually occurs during middle age or later and increases in occurrence with age. Myelomas are slightly more common in males than in females and can affect any of the marrow-con
as seen in nonmalignantosteoporosisor what appear to be punched out or lytic bone lesions. These lesions may causepainand even breaks orfracturesof the weakened bones. They may cause other systemic problems listed below. People often refer to multiple myeloma simply as myeloma (also termed Kahler...
Multiple myeloma can cause problems including: Bone problems. Your bones can become weaker, leading to fractures. Blood problems. You might get anemia, which means your body doesn't have enough red blood cells. This can make you tired and pale and cause heart problems. You might also have ...
Multiple Myeloma Multiple myeloma is a blood cancer formed by malignant plasma cells and typically originates in the bone marrow. What is Multiple Myeloma? Normal plasma cells are found in the bone marrow and are an important part of the immune system. Through a complex, multi-step process, ...
Multiple myeloma is characterized by the malignant proliferation of plasma cells, causing extensive skeletal osteolytic destruction, osteopenia, and pathologic fractures. Bone scintigraphy is unsuitable for assessing multiple myeloma due to its osteolyti
Vertebral fractures after discontinuation of denosumab: A post hoc analysis of the randomized placebo-controlled FREEDOM trial and its extension. J Bone Miner Res 2018;33:190-198. MYEL-I 1 of 3 • IMPEDE Score for Risk Stratiication (points assigned), Myeloma Risk Factors: Modiied: Low-...
Some myeloma cells produce only light chain fragments of immunoglobulins, known as "free light chains." When found in the urine, these are termed Bence Jones proteins. They can lead to specific complications like bone damage & fractures, kidney damage, immunodeficiency,hyperviscosity syndrome, etc....