Multiple myeloma is a type of blood cancer. It starts in your bone marrow, the spongy tissue inside bones. This is where your body makes blood cells, including a certain type called plasma cells. These cells can grow out of control and crowd out the normal, healthy ones in your bone mar...
Multiple myeloma, malignant proliferation of cells within the bone marrow that usually occurs during middle age or later and increases in occurrence with age. Myelomas are slightly more common in males than in females and can affect any of the marrow-con
Bone and BonesOsteoblastsStromal CellsOsteolysisNeoplasm ProteinsBone RemodelingCell DifferentiationAntibodies, NeutralizingLymphocytesMultiple myeloma (MM) is a hematologic malignancy of differentiated plasma cells that accumulates and proliferates in the bone marrow. MM patients often develop bone disease ...
A type of white blood cell called a plasma cell makes antibodies that fight infections in your body. When you have multiple myeloma, these cells multiply the wrong way. They let too much protein (called immunoglobulin) into your bones and blood. It builds up throughout your body and damages...
A high level of M protein in the blood is the hallmark characteristic of multiple myeloma. Healthy Bone Marrow White Blood Cell Red Blood Cell Abnormal Plasma Cell Normal Plasma Cell Bone Marrow with Multiple Myeloma Multiple myeloma typically occurs in bone marrow in the spine, pelvic bones, ...
The meaning of MULTIPLE MYELOMA is a disease of bone marrow that is characterized by the presence of numerous myelomas in various bones of the body.
Multiple myeloma (MM) is an osteolytic malignancy that is incurable due to the emergence of treatment resistant disease. Defining how, when and where myeloma cell intrinsic and extrinsic bone microenvironmental mechanisms cause relapse is challenging wit
(plasma cells) that depend on the bone marrow microenvironment for growth and survival. Thus, multiple myeloma is characterized by infiltration and growth of malignant plasma cells in the bone marrow accompanied by osteolytic lesions and fractures of the affected bones (Furukawa and Kikuchi 2015; ...
Signs and symptoms of multiple myeloma include bone pain, which may be present in three-fourths of patients. Osteolytic lesions and compression fractures may be seen in the axial skeleton and proximal long bones—the most common being the spine. There is an increased osteoclastic activity in mye...
Multiple myeloma is ablood cancerthat occurs when white blood cells, calledplasmacells, increase out of control in the bones. Myeloma destroys the bone by making osteoclasts – cells that break down old bones – become more active and weaken your bones. At the same time, myeloma cells slow ...