In multiple myeloma, cancerous plasma cells multiply rapidly in the bone marrow and invade the outer layers of the bones. This can weaken bones so much that minimal trauma can cause a bone fracture at the cancer site. The myeloma plasma cells also make too much of one specific type of imm...
Multiple myelomais a type of blood cancer. It starts in your bone marrow, the spongy tissue inside bones. This is where your body makes blood cells, including a certain type called plasma cells. These cells can grow out of control and crowd out the normal, healthy ones in your bone marro...
Multiple myeloma is a blood cancer that occurs when white blood cells, called plasma cells, increase out of control in the bones. Myeloma destroys the bone by making osteoclasts – cells that break down old bones – become more active and weaken your bones. At the same time, myeloma cells ...
Myeloma cells prevent bone cells from forming new bone and increase the absorption of bone already laid down, resulting in weak, thin bones characterized by holes (resembling holes in Swiss cheese) or “lytic lesions.” These lytic lesions can cause significant bone pain and increase the risk of...
Plasma cells are mainly found in the bone marrow, the hollow area within the bones.Because plasma cells are found in the blood, myeloma is considered a hematologic or blood cancer. The word “multiple” is often used because the malignant cells usually affect multiple areas of the bone marrow...
Multiple MyelomaReference work entry pp 521 Cite this reference work entry Encyclopedia of Radiation Oncology Caspian Oliai 143 Accesses Definition Collections of abnormal plasma cells in bones where they cause lytic lesions, and in the bone marrow where they interfere with hematopoiesis. Most cases ...
Bone and BonesOsteoblastsStromal CellsOsteolysisNeoplasm ProteinsBone RemodelingCell DifferentiationAntibodies, NeutralizingLymphocytesMultiple myeloma (MM) is a hematologic malignancy of differentiated plasma cells that accumulates and proliferates in the bone marrow. MM patients often develop bone disease ...
Multiple myeloma. Multiple myeloma cells are abnormal plasma cells (a type of white blood cell) that build up in the bone marrow and form tumors in many bones of the body. Normal plasma cells make antibodies to help the body fight infection and disease. As the number of multiple myeloma ce...
Presenting signs and symptoms of multiple myeloma (MM) include bone pain, pathologic fractures, weakness, anemia, infection (often pneumococcal), hypercalcemia, spinal cord compression, and acute kidney injury. In approximately 30% of cases, MM is discovered through routine blood screening when patient...
Thus, multiple myeloma is characterized by infiltration and growth of malignant plasma cells in the bone marrow accompanied by osteolytic lesions and fractures of the affected bones (Furukawa and Kikuchi 2015; Cheng et al. 2021; Rajkumar 2022). Thus, the bone marrow microenvironment plays an ...