Multiple myeloma is a relatively common malignancy of the elderly. Pathological fractures are among the most common presenting features, especially in patients with persistent lumbar pain. However, facing a patient presenting a vertebral fracture due to an osteolytic lesion, a metastatic cancer is ...
The median age of patients diagnosed with multiple myeloma55is approximately 70 years, with only 2% being younger than 40 years. Bone pain is usually the first symptom, with lesions by the malignant cells potentially causingosteoporosisandpathological fractures, especially in thevertebral bodies. As ...
Multiple Myeloma (MM) is a malignant proliferative disease of plasma cells in the bone marrow that remains largely untreatable. Patients develop osteolytic lesions, which frequently lead to skeletal-related events and pathological fractures.Myeloma-induced bone destruction is based on increased bone ...
The anemia of multiple myeloma (MM) is multifactorial, including physical replacement of normal hemopoiesis by tumor cells, renal failure and cytokines whi... B Barlogie,T Beck - 《Stem Cells》 被引量: 116发表: 1993年 New Insights into the Treatment of Multiple Myeloma with Histone Deacetylase...
Interactions between multiple myeloma (MM) and bone marrow (BM) are well documented to support tumour growth, yet the cellular mechanisms underlying pain in MM are poorly understood. We have used in vivo murine models of MM to show significant induc
Multiple myeloma (MM) is an osteolytic malignancy that is incurable due to the emergence of treatment resistant disease. Defining how, when and where myeloma cell intrinsic and extrinsic bone microenvironmental mechanisms cause relapse is challenging wit
1、Multiple MyelomaMM,浆细胞病(plasma cell dyscrasia)是指浆细胞或产生免疫球蛋白的B淋巴过度增殖所引起的一组疾病,血清或尿中出现过量的单克隆免疫球蛋白或其轻链或重链片段为其特征的一组疾病。 浆细胞病在临床上可分为两类:一类为具有明显临床症状和病理特征的恶性浆细胞病。 另一类为无明显临床症状的良性...
The recently updated Durie/Salmon PLUS staging system published in 2006 highlights the many advances that have been made in the imaging of multiple myeloma, a common malignancy of plasma cells. In th...
外科学教学课件:Multiple Myeloma.ppt,Lab and accessory tests Biochemistry examination Hyperglobulinemia and Hypoalbuminemia Cr and BUN Hypercalcemia AKP Beta-2 microglobulin LDH Increased levels may indicate a poorer prognosis. CRP IL-6 Lab and accessory
Multiple myeloma may be associated with extensive bone destruction, impending or present pathological fracture, and intractable pain. However, surgical intervention is rarely indicated since local bone crises are effectively managed with... Y Kollender,I Meller,JC Wittig,... 被引量: 4发表: 2005年...