The National Microbiome Data Collaborative (NMDC) Data Portal (https://data.microbiomedata.org) supports microbiome multi-omics data exploration and access through an integrated, distributed data framework aligned with the FAIR (Findable, Accessible, Interoperable and Reusable) data pr...
With the advancement of high-throughput sequencing technologies, the integration of multi-omics and multi-modal data has become an important trend in the study of complex diseases. Multi-omics/multi-modal data provide new perspectives for a deeper understanding of the pathogenesis and development of ...
In this collection, we present a series of multi-omics studies where the authors have used innovative means to maximize the accessibility and reusability of their datasets.
Our study identifies reference-free ‘absolute’ feature quantification as the root cause of irreproducibility in multi-omics measurement and data integration and establishes the advantages of ratio-based multi-omics profiling with common reference materials....
Knowledge Base Commons (KBCommons) v1.1 is a universal and all-inclusive web-based framework providing generic functionalities for storing, sharing, analyzing, exploring, integrating and visualizing multiple organisms’ genomics and integrative omics data. KBCommons is designed and developed to integrate ...
The accumulation of various multi-omics data and computational approaches for data integration can accelerate the development of precision medicine. However, the algorithm development for multi-omics data integration remains a pressing challenge. Here, w
data other omics data types, such as miRNA (microRNA) expression, methylation or copy number alterations, can be used to improve the model accuracy for patient stratification. For example, somatic copy number alterations provide good biomarkers for cancer subtype classification [5]. Data integration...
When there are overlapping samples from different omics data types, the t-statistics from different data types could be correlated. In the next subsection, we will further propose a permutation strategy to calculate FDR while accounting for potential sample correlation. We applied the R limma ...
Transglutaminase 2 (TG2) is a multifunctional protein that can function as a transglutaminase, G protein, kinase, protein disulfide isomerase, and as an adaptor protein. These multiple biochemical activities of TG2 account for, at least in part, its involvement in a wide variety of cellular proc...
4月week2文献阅读2:MOBCdb: a comprehensive database integrating multi‑omics data on breast cancer for precision medicine MOBCdb:一个综合了乳腺癌多组学数据的精确医学数据库 Abstract Background : Breast cancer is one of the most frequently diagnosed cancers among women worldwide, characterized by di...