High PD-L1 expression drives glycolysis via an Akt/mTOR/HIF-1 alpha axis in acute myeloid leukemiaprogrammed cell death 1 ligand 1glycolysisacute myeloid leukemiametabolismsignaling pathwayAcute myeloid leukemia (AML) is a hematological malignancy derived from immature myeloid cells, which have the ...
Moreover, metformin reversed EMT in OSCC by inhibiting the mTOR-associated HIF-1 alpha/PKM2/STAT3 signaling pathway. Overall, the present findings characterized a novel mechanism via which metformin modulated EMT in OSCC.Yin, WeihuangLiu, YangLiu, XinchenMa, XiaozhouSun, BinYu, Ziying...
1Yun1Ho1Jin1Guang1Yu1Li1Liang1chang1Yan1EBSCO_AspPlos One摇Choi YH,Jin GY,Li LC,et al. Inhibition of protein kinase C delta attenuates allergic airway inflammation through suppression of PI3K / Akt / mTOR / HIF鄄1 alpha / VEGF pathway [ J ] . PLoS One, 2013,8(11) :e81773郾...
593 POSTER Rational design of effective therapy combining irinotecan and rapamycin to target mTOR/HIF-1 alpha axis in colon cancerPencreachE.ArriveM.RaffelsbergerW.Lelong-RebelI.LarsenA.ingentaconnectEuropean Journal of Cancer Supplement
IMPLICATIONS OF DENDRITIC CELLS (DC) IN HYPOXIA-MEDIATED IMMUNE CHANGES. ROLE OF mTOR AND HIF-1[alpha] IN DC MATURATION.An abstract is unavailable. This article is available as a PDF only.RamaInésBrueneBernhardTorrasJoanKoehlRomanCruzado
Taken together, this work reports that HIF-1 alpha promotes viability and migration of activated B cell-like cells under hypoxia, which might involve the transcription of CXCR4 and the activation of the AKT/mTOR pathway. The finding may provide novel lights in the management of DCBCL....
593 POSTER Rational design of effective therapy combining irinotecan and rapamycin to target mTOR/HIF-1 alpha axis in colon cancerWe focused attention to the prognostic and predictive value of epidermal growth factor receptor (EGFR) expression HER2/neu expresion and some genetic alterations in an ...
1a,25-Dihydroxyvitamin D3 upregulates HIF-1 and TREM-1 via mTOR signalingTREM-11 alpha25-dihydroxyviamin D-3mTORMonocytesMacrophagesTriggering receptor expressed on myeloid cells-1 (KimHanyangJinHanyangHeeHanyangTae-HwanHanyangYongjinHanyangKwon
Therefore, the aim of the present study was to investigate the therapeutic effects of curcumin against chronic renal failure (CRF) in a rat model induced by 5/6 nephrectomy through inhibition of mTOR/HIF-1 alpha/VEGF signaling. A total of 70 male Sprague Dawley rats were divided into seven ...
mTORMonocytesMacrophagesTriggering receptor expressed on myeloid cells-1 (TREM-1) is induced by 1 alpha,25-dihydroxyvitamin D-3 (1,25(OH)(2)D-3) in human monocytes/macrophages and epithelial cells. However, little information is available regarding the mechanism of 1,25(OH)(2)D-3-induced ...