(2007) Partial duplications of the MSH2 and MLH1 genes in hereditary nonpolyposis colorectal cancer. Eur J Hum Genet; 15: 383-386.Baert-Desurmont S, Buisine MP, Bessenay E, et al. Partial duplications of the MSH2 and MLH1 genes in hereditary nonpolyposis colorectal cancer. Eur J Hum ...
Cellular DNA is subjected to continual attack, both by reactive species inside cells and by environmental agents. Toxic and mutagenic consequences are minimized by distinct pathways of repair, and 130 known human DNA repair genes are des... RD Wood,M Mitchell,JG Sgouros,... - 《Science》 被...
Variant human MLH1 and MSH2 genes are provided. Methods of using these variant genes to diagnose hereditary non-polyposis colorectal cancer (HNPCC) and/or determine a patient's susceptibility to developing HNPCC are also provided. Methods and compositions for identifying new variant MLH1 of MSH2 ...
Hereditary non-polyposis colorectal cancer is an autosomal dominant condition due to germline mutations in DNA-mismatch-repair genes, in particular MLH1, MSH2 and MSH6. Here we describe the application of a novel technique for the detection of genomic de
Mismatch repair genes MSH2 and MLH1 are considered to be the two major genes that are responsible for hereditary nonpolyposis colorectal cancer (HNPCC). Germline heterozygous inactivating mutations of MSH2 and MLH1 have been identified previously in a substantial fraction of individuals who are predisp...
Germline mutations in four human mismatch repair genes (MSH2, MLH1, PMS1, and PMS2) have been reported to cause hereditary non-polyposis colon cancer syndrome (HNPCC). The identification of germline mutations in HNPCC kindreds allows precise diagnosis and accurate predictive testing. To investigate...
Dictyostelium discoideum, a novel system for cancer research Recently, we have cloned two major human homologue repair genes in the MMR pathway (Msh2 and Mlh1) from this model system. Sequencing analyses indicate that these two genes have 40% identity and 55% similarity to their human ... XS...
Hereditary nonpolyposis colorectal cancer: Frequent occurrence of large genomic deletions in MSH2 and MLH1 genes Hereditary nonpolyposis colorectal cancer (HNPCC) is often caused by a deficiency in DNA mismatch repair. By using conventional methods of mutation analysi... Y Wang,W Friedl,C Lamberti,...
Hereditary nonpolyposis colorectal cancer: frequent occurrence of large genomic deletions in MSH2 and MLH1 genes. Hereditary nonpolyposis colorectal cancer (HNPCC) is often caused by a deficiency in DNA mismatch repair. By using conventional methods of mutation analysi... Y Wang,W Friedl,C Lamberti...
Germline mutations in the mismatch repair (MMR) genes MLH1 , MSH2 , MSH6 , or PMS2 can cause Lynch syndrome. This syndrome, also known as hereditary nonpol... J Ou,RC Niessen,J Vonk,... - 《Human Mutation》 被引量: 168发表: 2010年 Characterization of MLH1 and MSH2 DNA mismatch ...