First, we analyzed all DNA samples by a well-established and quick method, by methylation-specific PCR (MSP) for methyla- tion of mismatch repair gene promoters most frequently involved in human cancers, namely MLH1, MSH6, PMS2, and MSH2. The findings were validated using a highly sensitive...
Human MSH6, which stands for mutS homolog 6, is a member of the MMR family that is responsible for the repair of post-replicative mismatched DNA bases. It is also one of the proteins with gene mutations that are associated with a high risk of developing Lynch syndrome,...