Knoll B (2010) Actin-mediated gene expression in neurons: the MRTF-SRF connection. Biol Chem 391(6):591-597Knoll B. Actin-mediated gene expression in neurons: the MRTF-SRF connection. Biol Chem 391, 591-597 (2010).Knoll B (2010) Actin-mediated gene expression in neurons: the MRTF-SRF...
MRTF/SRF-IN-1 | MedChemExpress (MCE) 英文名称: 总访问: 34 国产/进口: 进口 半年访问: 13 产地/品牌: MedChemExpress(MCE) 产品类别: 生化试剂 规格: 电询 最后更新: 2023-5-4 货号: HY-153078 CAS 号: 1922098-90-5 参考报价: 电询 立即询价 电话咨询 ...
Inhibition of actomyosin or the MRTF/SRF pathway decreased FGFR1 expression in hMSCs, fibroblasts and MG63 cells. To our knowledge, this is the first time FGFR1 expression is shown to be regulated through a mechanosensitive pathway in hMSCs. These results add to the sparse literature on FGFR1 ...
Interpretation Our study is the first, to our knowledge, to show that silencing the MRTF/SRF pathway significantly decreases matrix contraction, fibroblast protrusive behaviour, matrix degradation, and MMP gene expression in fibrotic human conjunctival fibroblasts. Our study suggests that inhibiting the ...
The myocardin-related transcription factor/serum response factor (MRTF/SRF) pathway represents a promising therapeutic target to prevent fibrosis. We have tested the effects of new pharmacological inhibitors of MRTF/SRF signalling in a preclinical model
Our findings suggest that integrin-adhesion-induced MRTF-A–SRF activation and ISG15 expression constitute a newly discovered signalling circuit that promotes cell migration and invasion. 展开 关键词: Cell migration ISG15 Integrin MRTF-A SRF
CCG-203971 是一种第二代 Rho/MRTF/SRF 通路抑制剂,CCG-203971 可抑制 PC-3 细胞迁移(IC50值为4.2 μM)。 产品性质 英文别名(English Synonym) CCG-203971 中文名称(Chinese Name) / 靶点(Target) others 通路(Pathway) GPCR/G Protein CAS号(CAS NO.) ...
, 113989 article iqgap1 and nwasp promote human cancer cell dissemination and metastasis by regulatingβ1-integrin via fak and mrtf/srf author links open overlay panel camilla cerutti 1 2 3 , serena lucotti 4 6 , sofia t. menendez 2 7 , nicolas reymond 2 , ritu garg 2 , ignacio a....
We further demonstrate that the MRTF-SRF axis exerts transcriptional regulations of the TGF-尾 and BMP signaling pathway, critical developmental cues for brown adipocyte development. TGF-尾 signaling activity was significantly attenuated, whereas that of the BMP pathway augmented by inhibition of SRF ...
RNA sequencing revealed that cytarabine treatment promoted MRTF-SRF pathway activation. MRTF inhibition using CCG-203971 augmented the anti-tumor effects of chemotherapy in our AML mouse model, as well as suppressed the migration of chemoresistant C1498 cells. Conclusions: These results provide novel ...