MRTF/SRF-IN-1 | MedChemExpress (MCE) 英文名称: 总访问: 68 国产/进口: 进口 半年访问: 7 产地/品牌: MedChemExpress(MCE) 产品类别: 生化试剂 规格: 电询 最后更新: 2025-2-13 货号: HY-153078 CAS 号: 1922098-90-5 参考报价: 电询 立即询价 电话咨询 ...
CCG-203971 是一种第二代 Rho/MRTF/SRF 通路抑制剂,CCG-203971 可抑制 PC-3 细胞迁移(IC50值为4.2 μM)。 产品性质 英文别名(English Synonym) CCG-203971 中文名称(Chinese Name) / 靶点(Target) others 通路(Pathway) GPCR/G Protein CAS号(CAS NO.) ...
We further demonstrate that the MRTF-SRF axis exerts transcriptional regulations of the TGF-尾 and BMP signaling pathway, critical developmental cues for brown adipocyte development. TGF-尾 signaling activity was significantly attenuated, whereas that of the BMP pathway augmented by inhibition of SRF ...
MRTF-i-2 also reduced active β1-integrin at the cell surface (Figure 5K). The MRTFis had no effect on IQGAP1 expression but, interestingly, reduced NWASP levels (Figure S5L), suggesting a positive feedback loop whereby NWASP acts via the MRTF-SRF complex to induce β1-integrin ...
Interpretation Our study is the first, to our knowledge, to show that silencing the MRTF/SRF pathway significantly decreases matrix contraction, fibroblast protrusive behaviour, matrix degradation, and MMP gene expression in fibrotic human conjunctival fibroblasts. Our study suggests that inhibiting the ...
The myocardin-related transcription factor/serum response factor (MRTF/SRF) pathway represents a promising therapeutic target to prevent fibrosis. We have tested the effects of new pharmacological inhibitors of MRTF/SRF signalling in a preclinical model
MRTF-A is also implicated in vascular remodelling and epithelial to mesenchyme transition (EMT). The MRTF-A/SRF axis is highly relevant to fibrosis in systemic sclerosis (SSc).MethodsMRTF-A signal transduction was studied in healthy ... A Singh,X Shiwen,J Nikitorowicz-Buniak,... - 《Annal...
Our findings suggest that integrin-adhesion-induced MRTF-A–SRF activation and ISG15 expression constitute a newly discovered signalling circuit that promotes cell migration and invasion. 展开 关键词: Cell migration ISG15 Integrin MRTF-A SRF
Here, I focus on the nervous system, where the actin-MRTF-SRF entity governs multiple aspects of neuronal motility.doi:10.1515/BC.2010.061Bernd KnllBiological ChemistryKnoll B. Actin-mediated gene expression in neurons: the MRTF-SRF connection. Biol Chem 2010: 391: 591-597....
The morphological transformation of adipogenic progenitors into mature adipocytes requires dissolution of actin cytoskeleton with loss of myocardin-related transcription factor(MRTF)/serum response factor(SRF)activity.Circadian clock confers temporal control in adipogenic differentiation,while the actin cytoskel...