CCG-203971 是一种第二代 Rho/MRTF/SRF 通路抑制剂,CCG-203971 可抑制 PC-3 细胞迁移(IC50值为4.2 μM)。 产品性质 英文别名(English Synonym) CCG-203971 中文名称(Chinese Name) / 靶点(Target) others 通路(Pathway) GPCR/G Protein CAS号(CAS NO.) ...
MRTF/SRF-IN-1 | MedChemExpress (MCE) 英文名称: 总访问: 71 国产/进口: 进口 半年访问: 10 产地/品牌: MedChemExpress(MCE) 产品类别: 生化试剂 规格: 电询 最后更新: 2025-2-13 货号: HY-153078 CAS 号: 1922098-90-5 参考报价: 电询 立即询价 电话咨询 ...
We further demonstrate that the MRTF-SRF axis exerts transcriptional regulations of the TGF-尾 and BMP signaling pathway, critical developmental cues for brown adipocyte development. TGF-尾 signaling activity was significantly attenuated, whereas that of the BMP pathway augmented by inhibition of SRF ...
We used vav-iCre to inactivate MRTF-SRF signaling early during hematopoietic development. In both Srf- and Mrtf-deleted animals, hematopoiesis in fetal liver and spleen is intact but does not become established in fetal bone marrow. Srf-null HSC progenitor cells (HSC/Ps) fail to effectively ...
Interpretation Our study is the first, to our knowledge, to show that silencing the MRTF/SRF pathway significantly decreases matrix contraction, fibroblast protrusive behaviour, matrix degradation, and MMP gene expression in fibrotic human conjunctival fibroblasts. Our study suggests that inhibiting the ...
The myocardin-related transcription factor/serum response factor (MRTF/SRF) pathway represents a promising therapeutic target to prevent fibrosis. We have tested the effects of new pharmacological inhibitors of MRTF/SRF signalling in a preclinical model
Knoll B. Actin-mediated gene expression in neurons: the MRTF-SRF connection. Biol Chem 2010: 391: 591-597.Knoll B (2010) Actin-mediated gene expression in neurons: the MRTF-SRF connection. Biol Chem 391(6):591-597Knoll B (2010) Actin-mediated gene expression in neurons: the MRTF-SRF ...
The morphological transformation of adipogenic progenitors into mature adipocytes requires dissolution of actin cytoskeleton with loss of myocardin-related transcription factor(MRTF)/serum response factor(SRF)activity.Circadian clock confers temporal control in adipogenic differentiation,while the actin ...
Small EM. (2012) The actin-MRTF-SRF gene regulatory axis and myofibroblast differentiation. J Cardiovasc Transl Res 5: 794-804.Small EM. The actin-MRTF-SRF gene regulatory axis and myofibroblast differentiation. J Cardiovasc Transl Res. 2012;5:794-804....
We found that TRPM7 function regulates RhoA activity and subsequently actin polymerization, MRTF-A-Filamin A complex formation and MRTF-A/SRF target gene expression. Mechanistically, TRPM7 signaling relies on TRPM7 channel-mediated Mginflux and phosphorylation of RhoA by TRPM7 kinase. Pharmacological...