In particular, personalized mRNA vaccines against neoepitopes are promising and have shown efficacy in early studies in various malignant tumors such as breast cancer.Conclusion : mRNA vaccination has the potential to improve the survival of patients with breast cancer.Schmidt, Marcus...
Despite the advantages of mRNA cancer vaccines, there are some challenges that hinder their widespread application in clinical settings. Firstly, current trials have shown that mRNA cancer vaccines are not potent enough to elicit a response that will drastically change patients’ outcomes. Secondly, th...
[20] Wu C W, Duan Y J, Gong S M, et al. Identifiation of tumor antigens and immune subtypes for the development of mRNA vaccines and individualized immunotherapy in soft tissue sarcoma[J/OL]. Cancers, 2022, 14(2): 448[2022-03-...
1. mRNA vaccines and mRNA cancer vaccines In 1961, Brenner et al.1 first discovered mRNA, which is a key intermediate molecule necessary for expressing genes as proteins and contains codon information corresponding to amino acids (basic units of proteins)2. In 1990, Wolff et al.3 first showed...
Fig. 3 The preparation diagram of mRNA vaccines 3 mRNA疫苗的载体递送系统 尽管mRNA疫苗具有巨大的应用前景,但其仍然面临着体外运输和储存困难、体内递送过程中稳定性不足等挑战。在此基础上,开发安全高效的mRNA疫苗递送系统,在保护m...
Immuno-oncology has witnessed remarkable advancements in the past decade, revolutionizing the landscape of cancer therapeutics in an encouraging manner. Among the diverse immunotherapy strategies, mRNA vaccines have ushered in a new era for the therapeut
assisting tumor cells in evading immune system responses. Furthermore, the tumor microenvironment has been shown to increase the propensity of tumors to metastasize to other parts of the body. mRNA vaccines, as novel strategies for cancer immunotherapy, also greatly affect the tumor microenvironment [...
We focus on adverse events from mRNA applications for protein replacement and gene editing therapies as well as vaccines, tracing common biochemical and cellular pathways. The potential and limitations of existing models and tools used to screen for on-target efficacy and de-risk off-target toxicity...
A series of advancements occurred recently when mRNA vaccines were used to prevent triple-negative breast cancer and lung carcinoma using mRNAs encoding MUC1 and herpes simplex virus I thymidine kinase, respectively [33, 34]. The application has been utilized in prevention of cancer and infectious ...
[21] Oberli M A, Reichmuth A M, Dorkin J R, et al. Lipid nanoparticle assisted mRNA delivery for potent cancer immunotherapy[J]. Nano Lett, 2017, 17(3): 1326-1335. [22] Miao L, Li L X, Huang Y X, et...