mRNA vaccines have become a promising platform for cancer immunotherapy. During vaccination, naked or vehicle loaded mRNA vaccines efficiently express tumor antigens in antigen-presenting cells (APCs), facilitate APC activation and innate/adaptive immune stimulation. mRNA cancer vaccine precedes other ...
[1]Chaudhary, Namit et al. “mRNA vaccines forinfectious diseases: principles, delivery and clinicaltranslation.” Nature reviews. Drug discovery, 1–22. 25 Aug. 2021,doi:10.1038/s41573-021-00283-5 [2]Miao, Lei et al. “mRNA vaccine fo...
[1]Chaudhary, Namit et al. “mRNA vaccines forinfectious diseases: principles, delivery and clinicaltranslation.” Nature reviews. Drug discovery, 1–22. 25 Aug. 2021,doi:10.1038/s41573-021-00283-5 [2]Miao, Lei et al. “mRNA vaccine for cancerimmunotherapy.” Molecular cancer vol. 20,1 ...
[2]Miao, Lei et al. “mRNA vaccine for cancerimmunotherapy.” Molecular cancer vol. 20,1 41. 25 Feb. 2021,doi:10.1186/s12943-021-01335-5 [3]Xie, Wen et al. “Evolution of the market for mRNAtechnology.” Nature reviews. Drug discovery, 10.1038/d41573-021-00147-y. 2 Sep.2021, ...
mRNA vaccine activated T cells and stimulated antibody production, causing tumors to shrink in the treated mice. Also, in contrast to untreated mice, the vaccinated mice did not show any metastasis to the lung. These results demonstrate that the hydrogel has great potential for achieving long-...
[27] Miao L, Zhang Y, Huang L. mRNA vaccine for cancer immunotherapy[J]. Mol Cancer, 2021, 20(1): 41. DOI: 10.1186/s12943-021-01335-5. [28] Karpenko L I, Rudometov A P, Sharabrin S V, et al. Deliv...
9. Namit Chaudhary, Drew Weissman, Kathryn A Whitehead. mRNA vaccines for infectious diseases: principles, delivery and clinical translation. Nat Rev Drug Discov. 2021 Nov;20(11):817-838. 10. Lei Miao, Yu Zhang, Leaf Huang. mRNA vaccine for cancer immunotherapy. Mol Cancer. 2021 Feb 25;...
mRNA vaccines have become a promising platform for cancer immunotherapy. During vaccination, naked or vehicle loaded mRNA vaccines efficiently express tumor antigens in antigen-presenting cells (APCs), facilitate APC activation and innate/adaptive immune stimulation. mRNA cancer vaccine precedes other conve...
参考文献 1.RNA therapy: rich history, various applications and unlimited future prospects. 2.RNA therapy: current status and future potential. 3.mRNA vaccine for cancer immunotherapy. 4.Drug delivery systems for RNA therapeutics.
mRNA Cancer vaccine Tumor-associated antigens Neoantigens mRNA delivery vectors Adjuvants Administration routes 1. mRNA vaccines and mRNA cancer vaccines In 1961, Brenner et al.1 first discovered mRNA, which is a key intermediate molecule necessary for expressing genes as proteins and contains codon ...