several doses of administration are required. One cannot achieve this amount of vaccine delivery if the vaccine induces considerable toxicity. A persistent theme in LNP vaccine development is the incorporation of biodegradable constituents into the LNPs to reduce off-target systemic toxicity [122]....
Abbreviations: GBM, glioblastoma; HNC, head and neck cancer; HNSCC, head and neck squamous cell carcinoma; NSCLC, non-small-cell lung cancer; OC, ovarian cancer; PC, prostate cancer; PCV, personalized cellular vaccine; TNBC, triple-negative breast cancer. 2.1. Selected antigens or targets 2.1...
high-risk individuals, including those aged 80 years and older, as well as those aged 60–79 years, did not appear to be adequately protected against infection. Abu-Raddad et al. investigated the impact of mRNA vaccine boosters on SARS-CoV-2 omicron infection in 2,239...
mRNA vaccineImmune subtypesTumor antigensImmune landscapeImmune gene moduleAlgorithmLANDSCAPEPACKAGEPurposesCancer mRNA vaccines are a promising strategy and a hot topic in cancer immunotherapy. However, mRNA vaccines for breast cancer (BRCA) remain undeveloped. This study aimed to identify potential tumor ...
vaccine, the delivery system as well as administration route, involved in the optimization for its therapeutic application. In general, although mRNA cancer vaccines have advanced quickly, there have been many issues remain to be solved to promote the feasibility and efficacy [21,22]. To date, ...
vaccine in combi Combination application of mRNA vaccines and oncogene therapy Oncogene therapy often involves introducing wild-type copies of tumor suppressor genes or exploiting tumor-specific phenotypic changes to selectively target cancer cells. Tumor suppressor genes (TSGs) are essential for maintaining...
2024年5月31日,来自斯坦福大学医学院的研究团队在Science上发表了题为:Germline-mediated immunoediting sculpts breast cancer subtypes and metastatic proclivity的研究论文。 研究团队发现了一种新的癌症发生机制:种系表位负担(GEB),即从出生时的基因序列中可以“预测”几十年后体细胞是否可能演变为癌细胞。这一发现...
[23] Liu L, Wang Y H, Miao L, et al. Combination immunotherapy of MUC1 mRNA nano-vaccine and CTLA-4 blockade effectively inhibits growth of triple negative breast cancer[J]. Mol Ther, 2018, 26(1): 45-55. [24] Huang X, Zhang ...
[1]Reinhard, et al. "An RNA vaccine drives expansion and efficacy of claudin-CAR-T cells against solid tumors." Science 367.6476 (2020): 446-453. [2] BioNTech Presents Encouraging Phase 1/2 Follow-up Data for CAR-T Candidate BNT211 in Hard-To-Treat Solid Tumors at ESMO ...
Combination immunotherapy of MUC1 mRNA nano-vaccine and CTLA-4 blockade effectively inhibits growth of triple negative breast cancer. Mol. Ther. 26, 45–55 (2018). Article CAS PubMed Google Scholar Xiao, Y. et al. Combining p53 mRNA nanotherapy with immune checkpoint blockade reprograms the ...