The mRNA vaccine field is developing extremely rapidly; a large body of preclinical data has accumulated over the past several years, and multiple human clinical trials have been initiated. In this Review, we discuss current mRNA vaccine approaches, summarize the latest findings, highlight challenges...
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Furthermore, SARS and Ebola epidemic outbreaks and, more recently, the CODVID-19 pandemic, show that many of the current platforms are not well suited for a very fast, efficient, and cost-effective response. New vaccine technology approaches are thus necessary to improve our response to ...
Discoveries in the past decade have highlighted the potential of mRNA as a therapeutic target for cancer. Specifically, RNA sequencing revealed that, in addition to gene mutations, alterations in mRNA can contribute to the initiation and progression of cancer. Indeed, precursor mRNA processing, which...
Fig. 4 The commonly used mRNA vaccine delivery systems 3.1 脂质体及脂质复合物 脂质体是由具有亲水头部和疏水尾部的两亲性聚合物分子在水相溶液中形成的一种类似细胞膜的脂质结构,被认为是较为安全可靠的非病毒递送载体之一,也...
well tolerated for both prophylactic and therapeutic applications [7]. Messenger RNA (mRNA) vaccine has recently emerged as an appealing alternative to DNA vaccine for infectious disease preventions and anti-cancer treatments. Advantages of mRNA over DNA as cancer vaccine strategy include: (1) mRNAs...
Methods:Tumor-specific neoantigens and aberrantly overexpressed tumor-associated antigens were identified for glioblastoma and medulloblastoma tumors using our cancer immunogenomics pipeline called Open Reading Frame Antigen Network (O.R...
by T4 RNA ligase [17,37,247]. Notably, the intron splicing strategy has been used to create a SARS-CoV-2 vaccine (LNP-circRNA encoding the RBD region) with a potent cellular response and effective protection against different variants of concerns in mice and macaques. In addition, this vacc...
mRNA therapeutics have become the focus of molecular medicine research. Various mRNA applications have reached major milestones at high speed in the immuno-oncology field. This can be attributed to the knowledge that mRNA is one of nature’s core buildin
PD-1 and LAG-3) to improve the vaccine efficacy in the prostate cancer model [33]. The mRNA-2416, the mRNA encoding OX40 ligand (OX40L) that lacks efficient effects when used as monotherapy, was taken forward to a phase II expansion cohort in the combined treatment with durvalumab for ...