2024 年 3 月 5 号,国内学者在Biorxiv上发表文章:A 10-valent composite mRNA vaccine against both influenza and COVID-19,他们创造性地设计合成了一种新型 10 价 mRNA 新冠流感复合疫苗,称为 FLUCOV-10,该疫苗编码来自4种季节性流感病毒和2...
参考文献 [2] Pfizer Initiates Phase 3 Study of mRNA-Based Influenza Vaccine. Retrieved September 14, 2022 from https://www.pfizer.com/news/press-release/press-release-detail/pfizer-initiates-phase-3-study-mrna-based-influenza-vaccine. [3] Carascal MB, Pavon RDN, Rivera WL. Recent Progress i...
1.Norbert Pardi et al. Nucleoside-modified mRNA immunization elicits influenza virus hemagglutinin stalk-specific antibodies. Nature Communications, 2018; 9 6. 2. Antigen modifications improve nucleoside-modified mRNA-based influenza virus vaccines in mice,Molecular Therapy - Methods & Clinical Development,...
胰腺导管腺癌(PDAC)具有较低的突变负荷,因此传统的免疫疗法效果有限。BioNTech 公司开发了一款名为 Autogene cevumeran 的个性化 mRNA 新抗原疫苗,这是一款 mRNA 经过优化修饰的 mRNA-LNP 疫苗,旨在通过引发针对肿瘤特异性新抗原的 T 细胞反应来增...
2023年9月6号,上海生物制品研究所总经理李秀玲和研发部经理罗剑团队共同在Emerging Microbes & Infections发布文章:《An mRNA-based broad-spectrum vaccine candidate confers cross-protection against heterosubtypic influenza A viruses》,他们开发了一种基于流感保护抗原的多价流感mRNA疫苗,由甲型流感病毒的三种保守抗...
12. An alphavirus replicon particle chimera derived from venezuelan equine encephalitis and sindbis viruses is a potent gene-based vaccine delivery vector; 13. Self-Amplifying mRNA Vaccines Expressing Multiple Conserved Influenza Antigens Confer Protection against Homologous and Heterosubtypic Viral Challenge...
2018年,宾州大学Drew Weissman教授在Nature Communications发表文章Nucleoside-modified mRNA immunization elicits influenza virus hemagglutinin stalk-specific antibodies.pdf。他们研发出一款编码流感病毒全长HA蛋白的A/California/07/2009 HA mRNA流感疫苗,并且在动物模型中证实该款流感mRNA疫苗可以触发靶向流感病毒HA头部和茎...
参考文献:Xiong F, Zhang C, Shang B, Zheng M, Wang Q, Ding Y, Luo J, Li X. An mRNA-based broad-spectrum vaccine candidate confers cross-protection against heterosubtypic influenza A viruses. Emerg Microbes Infect. 2023 Dec;12(2):2256422. doi: 10.1080/22221751.2023.2256422. Epub 2023 ...
FDA批准的第一款基于RNA的寡核苷酸药物patisiran(一段短的干扰RNA用于治疗前白蛋白介导的遗传性淀粉样沉淀神经病(TTR))使用的就是LNP剂型,包含一种可电离脂质、d-Lin-MC3-DMA (MC3)、DSPC、胆固醇和PEG2000-DMG【25】。BioNTech的BNT162b2采用的是ALC-0315、ALC-0315、DSPC和胆固醇。目前看来,发现、测试和生产...
近日,我院耳鼻咽喉-头颈外科赵宇教授、任建君副研究员与生物治疗国家重点实验室宋相容研究员团队合作在疫苗领域国际权威期刊Npj Vaccines上发表题为mRNA-LNP vaccination-based immunotherapy augments CD8+ T cell responses against HPV-positive oropharyngeal cancer的研究论文,利用多组学技术系统性探究了mRNA-LNP疫苗对小鼠...