2024 年 3 月 5 号,国内学者在Biorxiv上发表文章:A 10-valent composite mRNA vaccine against both influenza and COVID-19,他们创造性地设计合成了一种新型 10 价 mRNA 新冠流感复合疫苗,称为 FLUCOV-10,该疫苗编码来自4种季节性流感病毒和2...
Therefore, to evaluate differences in immunogenicity and protection between mRNA influenza vaccine containing modified and unmodified nucleosides, mRNA encoding CA09 HA was administered to mice at doses of 5 and 30 μg at days 0 and 21. Control mice were given saline or LNP containing mRNA ...
参考文献 [2] Pfizer Initiates Phase 3 Study of mRNA-Based Influenza Vaccine. Retrieved September 14, 2022 from https://www.pfizer.com/news/press-release/press-release-detail/pfizer-initiates-phase-3-study-mrna-based-influenza-vaccine. [3] Carascal MB, Pavon RDN, Rivera WL. Recent Progress i...
题为A multivalent nucleoside-modified mRNA vaccine against all known influenza virus subtypes,通过产生核苷酸修饰的mRNA-脂质纳米颗粒(Lipid nanoparticle,LNP)表达所有已知流感病毒的HA抗原,该多价疫苗能够诱导多种抗体产生,并能够在小鼠中...
2018年,宾州大学Drew Weissman教授在Nature Communications发表文章Nucleoside-modified mRNA immunization elicits influenza virus hemagglutinin stalk-specific antibodies.pdf。他们研发出一款编码流感病毒全长HA蛋白的A/California/07/2009 HA mRNA流感疫苗,并且在动物模型中证实该款流感mRNA疫苗可以触发靶向流感病毒HA头部和茎...
12. An alphavirus replicon particle chimera derived from venezuelan equine encephalitis and sindbis viruses is a potent gene-based vaccine delivery vector; 13. Self-Amplifying mRNA Vaccines Expressing Multiple Conserved Influenza Antigens Confer Protection against Homologous and Heterosubtypic Viral Challenge...
of LNP-complexed mRNA encoding influenza virus HA elicited protective immune responses against homologous influenza virus challenge in mice. Similar results were obtained in ferrets and cynomolgus monkeys after immunization with one or two doses of 50–400 μg of a vaccine containing LNP-complexed mRN...
参考文献:Xiong F, Zhang C, Shang B, Zheng M, Wang Q, Ding Y, Luo J, Li X. An mRNA-based broad-spectrum vaccine candidate confers cross-protection against heterosubtypic influenza A viruses. Emerg Microbes Infect. 2023 Dec;12(2):2256422. doi: 10.1080/22221751.2023.2256422. Epub 2023 ...
2023年9月6号,上海生物制品研究所总经理李秀玲和研发部经理罗剑团队共同在Emerging Microbes & Infections发布文章:《An mRNA-based broad-spectrum vaccine candidate confers cross-protection against heterosubtypic influenza A viruses》,他们开发了一种基于流感保护抗原的多价流感mRNA疫苗,由甲型流感病毒的三种保守抗...
最初,DNA疫苗(DNA vaccine)被认为比mRNA疫苗(mRNA vaccine)更有前景,因为DNA更稳定。然而,由于进展缓慢,早期在小型动物中DNA疫苗令人鼓舞的结果并未在人中重现[5]。一个可能的原因是,注射的DNA必须穿过两个屏障,即质膜和核膜,到达转录(transcription,DNA转换成mRNA)发生的细胞分区。相反,mRNA疫苗只需要进入细胞质,在...