Thus, various vaccine approaches have been investigated to improve safety and efficacy. Here, we evaluate an mRNA influenza vaccine encoding hemagglutinin (HA) proteins in a BALB/c mouse model. The results show that mRNA vaccination elicits neutralizing and serum antibodies to ...
apply mRNA vaccination for the first time to infectious disease, demonstrating immunogenicity and/or protective effects against influenza virus in mice, ferrets and pigs.#Despite substantial improvements, influenza vaccine production—and availability—remain suboptimal. Influenza vaccines based on mRNA may ...
Vaccines are the best available countermeasure against infection, but vaccine effectiveness is low compared with other viral vaccines, and the induced immune response is narrow and short-lived. Furthermore, inactivated influenza virus vaccines focus on the induction of systemic IgG responses but do not...
mRNA vaccine candidate protects ferrets from H5N1 Jan. 15, 2025 No Comments There are currently three approved vaccines against the H5N1 avian influenza virus. However, they present challenges for large-scale virus cultivation in case of an outbreak and rapid update of vaccine strains to keep pace...
别名 CAIV-T、cold-adapted intranasal virus vaccine、flu vaccine + [8] 靶点- 作用机制 免疫刺激剂 治疗领域 感染呼吸系统疾病 在研适应症 流感病毒感染 非在研适应症 流感样症状麻疹腮腺炎+ [3] 原研机构 MedImmune LLC 在研机构 AstraZeneca AB 非在研机构 MedImmune LLC 最高研发阶段批准上市 首次获批日...
have developed an mRNA lipid nanoparticle (LNP) vaccine that contains antigens from all 20 known subtypes of influenza A and B viruses. The vaccine elicited high levels of antibodies in mice and ferrets, and protected animals against disease symptoms and death after infection.关键词:...
influenza virus vaccine mRNA nucleoside-modification lipid nanoparticle universal vaccine Sorry, something went wrong. Please try again and make sure cookies are enabled Cited by (195) The mRNA-LNP platform's lipid nanoparticle component used in preclinical vaccine studies is highly inflammatory ...
The A/Mallard/67S0/78 Avian-Human, but Not the A/Ann Arbor/6/60 Cold-Adapted, Influenza A/Kawasaki/86 (H1N1) Reassortant Virus Vaccine Retains Partial Viru... Characteristics of avian-human (ab) and cold-adapted (ca) influenza A/Kawasaki/9/86 (H1N1) reassortant vaccine viruses were comp...
all HA mRNA-LNP-immunized animals survived viral challenge, while those injected with poly(C) RNA-LNP needed to be euthanized (Fig.7a). As expected, no measurable HAI activity against the H5N1 virus was observed in mice immunized with the A/California/07/2009 HA mRNA-LNP vaccine (Fig.7b)...
Recombinant hemagglutinin subunit vaccine produced in a baculovirus expression vector system Recombinant subunit vaccines based on hemagglutinin from human Influenza virus have been developed and tested in healthy young adults and elderly. These ... Wilkinson,BE - - 被引量: 7发表: 1998年 加载更多来源...