Thus, various vaccine approaches have been investigated to improve safety and efficacy. Here, we evaluate an mRNA influenza vaccine encoding hemagglutinin (HA) proteins in a BALB/c mouse model. The results show that mRNA vaccination elicits neutralizing and serum antibodies to ...
apply mRNA vaccination for the first time to infectious disease, demonstrating immunogenicity and/or protective effects against influenza virus in mice, ferrets and pigs.#Despite substantial improvements, influenza vaccine production—and availability—remain suboptimal. Influenza vaccines based on mRNA may ...
Vaccines are the best available countermeasure against infection, but vaccine effectiveness is low compared with other viral vaccines, and the induced immune response is narrow and short-lived. Furthermore, inactivated influenza virus vaccines focus on the induction of systemic IgG responses but do not...
Strategic construction of mRNA vaccine derived from conserved and experimentally validated epitopes of avian influenza type A virus: a reverse vaccinology ... L Herrera-Ong - 《Clinical & Experimental Vaccine Research》 被引量: 0发表: 2023年 Improved influenza vaccine responses after expression of mul...
25, 26, 27 mRNA is encapsulated in an ∼80-nm LNP that mimics the size of an influenza virion (Figure 1A).28,29 In this study, we have harnessed the technology of nucleoside-modified mRNA-LNP vaccines to effectively deliver a universal influenza virus vaccine candidate that targets a ...
has received IND clearance from the FDA to begin a phase I study of ARCT-2304, a self-amplifying mRNA (sa-mRNA) vaccine candidate for active immunization to prevent pandemic influenza disease caused by H5N1 virus.Read More Bispecific inhibits neuraminidase while recruiting immune system Oct. 30...
Recent approval of mRNA vaccines for emergency use against COVID-19 is likely to promote rapid development of mRNA-based vaccines targeting a wide range of infectious diseases. Compared to conventional approaches, this vaccine modality promises comparable potency while substantially accelerating the pace ...
Influenza vaccinedoi:US6524588 B1RNA polymerase I transcription in vivo in transiently DNA-transfected cells has been used for expression of influenza vRNA molecules coding for chloramphenicol acetyltransferase (CAT) in anti-sense orientation. Influenza virus superinfection served to provide viral RNA ...
Inflammatory responses in influenza A virus infection IlkkaJulkunen, ...SampsaMatikainen, inVaccine, 2000 Influenza viruses are classified in three types (influenza A, B and C) of which influenza A is clinically the most important one. Influenza A virus is highly contagious and it infectsupper ...
mRNA lipid nanoparticle (LNP) vaccines would be useful during an influenza virus pandemic since they can be produced rapidly and do not require the generation of egg-adapted vaccine seed stocks. Highly pathogenic avian influenza viruses from H5 clade 2.3