have developed an mRNA lipid nanoparticle (LNP) vaccine that contains antigens from all 20 known subtypes of influenza A and B viruses. The vaccine elicited high levels of antibodies in mice and ferrets, and protected animals against disease symptoms and death after infection.关键词:...
A Universal Influenza Vaccine : Generating Broad Immunity Using N8 , an M2e / NP Fusion ProteinCruz, TracyGe, HongMilley, BobYalda, DoriceAmuel, CarstenHiggins, Debbie
Influenza A virus M2e Peptide vaccine Pigs Protection Swine flu 1. Introduction Influenza A viruses (IAV) in North American pigs are genetically diverse and include H3N2, H1N1 and H1N2 subtypes [1], [2]. Similar trends are also being reported from Europe [3]. Notably, there is a lack of...
Intranasal immunization in all these animal models led to effective protection against challenge infection with different strains of influenza virus.TamarBen-Yedidia&RuthArnonInformaworldHuman VaccinesBen Yedidia T, Arnon R. Towards an epitope based human vaccine for influenza[J].Hum Vaccin, 2005,1(3...
Influenza Vaccine (Live, Attenuated) Influenza is anRNA virusin theorthomyxovirusfamily. There are two major subtypes of influenza virus:influenza Aandinfluenza B. Both are importanthuman pathogens, although humans are not the natural host for influenza (wildaquatic birdsare the natural host). Inf...
mRNA-based drugs have tremendous potential as clinical treatments, however, a major challenge in realizing this drug class will promise to develop methods for safely delivering the bioactive agents with high efficiency and without activating the immune s
The immune escape of Omicron variants significantly subsides by the third dose of an mRNA vaccine. However, it is unclear how Omicron variant-neutralizing antibodies develop under repeated vaccination. We analyze blood samples from 41 BNT162b2 vaccinees following the course of three injections and ana...
The use, when preparing a vaccine composition containing a standard influenza virus vaccine, of an additive which consists of a core or core fraction of at least one influenza virus, especially a fraction containing protein M; and a vaccine composition thereby obtained. The use of said additive ...
Two types of vaccine are available for prevention of influenza. Inactivated vaccines consist of partially purified HA and NA preparations derived from virions produced in eggs or in cell culture or, in one case, purified recombinant HA produced in insect cells. Current vaccines contain one example...
If AIV infection can be controlled in poultry, it will control influenza infection in wild birds and ultimately in humans as well. An effective vaccine for poultry could help to stem the spread in poultry and wild bird population [52–54]. In Nov 2021 near the Indian city of Jodhpur, ...