have developed an mRNA lipid nanoparticle (LNP) vaccine that contains antigens from all 20 known subtypes of influenza A and B viruses. The vaccine elicited high levels of antibodies in mice and ferrets, and protected animals against disease symptoms and death after infection....
mRNA疫苗比其他类型的疫苗具有优势:它们的生产速度快,制造过程无细胞。与人类流感疫苗类似,目前还没有一种通用疫苗能够在家禽中预防所有高致病性禽流感病毒(Highly Pathogenic Avian Influenza Virus, HPAIV)。南方科技大学王鹏和贺云娇两位老师作为共同通讯作者发表了综述文章,汇总了IAV和禽流感病毒(Avian Influenza Virus...
3.Unmodified mRNA in LNPs constitutes a competitive technology for prophylactic vaccines. 4.Nucleoside-modified mRNA immunization elicits influenza virus hemagglutinin stalk-specific antibodies. 5.A Multi-Targeting, Nucleoside-Modified mRNA Influenza Virus Vaccine Provides Broad Protection in Mice 6.Self-Ampl...
大约八年后,他们在人体中评估了第一款mRNA疫苗,当时从黑色素瘤(melanoma)患者的肿瘤中提取了遗传物质,并用于合成mRNA,该mRNA作为一种自体疫苗(autologous vaccine)细胞集落刺激因子(granulocyte-macrophage colony-stimulating factor,GM-CSF)一同给药作为佐剂。这种方法被证明是安全的,并在一些患者中增加了抗肿瘤免疫反应...
2024 年 3 月 5 号,国内学者在Biorxiv上发表文章:A 10-valent composite mRNA vaccine against both influenza and COVID-19,他们创造性地设计合成了一种新型 10 价 mRNA 新冠流感复合疫苗,称为 FLUCOV-10,该疫苗编码来自4种季节性流感病毒和2...
mRNA vaccines represent a promising alternative to conventional vaccine approaches because of their high potency, capacity for rapid development and potential for low-cost manufacture and safe administration. However, their application has until recently been restricted by the instability and inefficient in...
12. An alphavirus replicon particle chimera derived from venezuelan equine encephalitis and sindbis viruses is a potent gene-based vaccine delivery vector; 13. Self-Amplifying mRNA Vaccines Expressing Multiple Conserved Influenza Antigens Confer Protection against Homologous and Heterosubtypic Viral Challenge...
2024 年 3 月 5 号,国内学者在 Biorxiv 上发表文章:A 10-valent composite mRNA vaccine against both influenza and COVID-19,他们创造性地设计合成了一种新型 10 价 mRNA 新冠流感复合疫苗,称为 FLUCOV-10,该疫苗编码来自4种季节性流感病毒和2种具有大流行潜力的禽流感病毒的血凝素 (HA) 蛋白,以及来自...
参考文献:Xiong F, Zhang C, Shang B, Zheng M, Wang Q, Ding Y, Luo J, Li X. An mRNA-based broad-spectrum vaccine candidate confers cross-protection against heterosubtypic influenza A viruses. Emerg Microbes Infect. 2023 Dec;12(2):2256422. doi: 10.1080/22221751.2023.2256422. Epub 2023 ...
用mRNA技术对抗癌症则是通过一种叫做“癌症疫苗”（cancer vaccine）的法疗来实现的。癌症疫苗的总体思路是让一个人的免疫系统可以精准区分肿瘤细胞和正常细胞，通过将肿瘤抗原以多种形式（如核酸、蛋白多肽等）导入患者体内，来刺激患者体内自身免疫系统的反应从而对肿瘤细胞进行清除。由于不同癌症患者的肿瘤细胞突变不同...