have developed an mRNA lipid nanoparticle (LNP) vaccine that contains antigens from all 20 known subtypes of influenza A and B viruses. The vaccine elicited high levels of antibodies in mice and ferrets, and protected animals against disease symptoms and death after infection....
6.2 mRNA-based vaccines The mRNA vaccine is a hopeful alternative to traditional vaccine methods in virtue of its high efficiency, rapid development capabilities, and the potential for low-cost manufacturing [154]. Recently, Moderna, Inc. has launched phase I clinical trials for mRNA-1273, which...
A TLR7-nanoparticle adjuvant promotes a broad immune response against heterologous strains of influenza and SARS-CoV-2 Article Open access 30 January 2023 Measles-based Zika vaccine induces long-term immunity and requires NS1 antibodies to protect the female reproductive tract Article Open access ...
It is exactly those benefits that suggest to us that mRNA vaccine technology has the potential to provide more effective, more tolerable, and more convenient vaccines for diseases which don’t yet have mRNA alternatives, such as influenza and shingles. Let’s take a closer look at the differenc...
The mRNA vaccine also induced cross-neutralizing antibodies against multiple other tick-borne flaviviruses and protected mice against the distantly related Langat virus. These data demonstrate the utility of the LNP-mRNA vaccine platform for the development of vaccines with protective activity against ...
mRNAs and mRNA vaccine The concept of mRNA-encoded drugs was discovered in the 1990s when direct injection of IVT mRNA into the mouse skeletal muscle showed encoded protein expression [56]. Preclinical research on IVT mRNA promotes the clinical development of mRNA-based vaccination against cancer an...
An avian influenza vaccine developed against one variant of the H5N1 virus may protect humans from future variantsdoi:10.1037/h0047708ShipmentsNuclear MaterialsCurrentProvideCoastal StatesRightsInnocentPassagesThe maritime transport of nuclear materials has created a conflict between two international law ...
Synthetic vaccinology is the process of using viral gene sequence information to accelerate vaccine development.2 For example, if a new influenza virus emerges anywhere in the world and is identified through genomic sequencing, the digitally transferred information can be used to synthesize nucleic acids...
The U.S. government will pay the vaccine maker Moderna $176 million to accelerate development of a pandemic influenza vaccine that could be used to treat bird flu in people, as concern grows about cases in dairy cows across the country, federal officials announced Tuesday. ...
A novel avian influenza subtype, A/H7N9, emerged in 2013 and represents a public health threat with pandemic potential. We have previously shown that DNA vaccine priming increases the magnitude and quality of antibody responses to H5N1 monovalent inactivated boost. We now report the safety and immu...