The first goal of this study was to explore color vision changes or impairments that occur in the normal aging mouse and in the double transgenic APPSWE/PSEN1∆E9(AD+) mouse. It was imperative for us to assess the spontaneous behavior of the mice that would be solely guided by visual st...
The series begins with an intriguing look at the possible connections between an endogenous retrovirus, the infectious agent of scrapie and accelerated senescence in a mouse model of early aging. 展开 关键词: Senescence Accelerated mouse strains Scrapie Murine leukemia virus Endogenous virus Learning ...
Telomeres, the ends of eukaryotic chromosomes, protect genome integrity and enable cell proliferation. Maintaining optimal telomere length in the germline and throughout life limits the risk of cancer and enables healthy aging. Telomeres in the house mouse,Mus musculus, are about five times longer th...
Thus, SAM-P/10 can serve as a spontaneous animal model of brain atrophy for a variety of studies of aging of the brain. A better understanding of neurodegenerative diseases with dementia should be forthcoming. 展开 关键词: Aging Animal model Avoidance learning Brain atrophy Inbred mice Learning ...
Chronic exposure to d-galactose ( D-Gal), which causes acceleration in aging and simulated symptoms of natural senescence, has been used as a reliable animal model of aging. However, the different influences of D-Gal on spatial and nonspatial cognition are as yet unclear. In the present stud...
To Study the effect of anti-aging and its mechanism of total saponins of Wu-He Dipsacus asper on skin of mice-aging model. Forty-eight mice were randomly divided into blank control group, model group, low-Dipsacus group, medium-Dipsacus group, high-Dipsacus group and positive control group(...
Prolongation of life span in the accelerated aging klotho mouse model, by low-dose-rate continuous γ irradiation 来自 国家科技图书文献中心 喜欢 0 阅读量: 26 作者: Nomura,T.,Sakai,K.,Ogata,H.,Magae,J. 摘要: While lifespan studies provide basic information f 年份: 2013 ...
Covering various areas, each chapter is written by a pioneering researcher who has developed an original vascular disease model. Notoriously difficult to reproduce... M Sata - Mouse Models of Vascular Diseases 被引量: 104发表: 2016年 Pathology of Mouse Models of Accelerated Aging Progeroid mouse ...
Using immunofluorescence and flow cytometry techniques, tdTomato cells were detected throughout the CNS, but not in peripheral tissues of adult Tmem119 tdTomato/+ mice. In addition, aging does not seem to influence TMEM119 expression as tdTomato cells were detectable in the CNS of older mice (...
Mapping of quantitative trait loci controlling lifespan in the short-lived fish Nothobranchius furzeri—a new vertebrate model for age research. Aging Cell 2012; 11: 252–261. 6 Wang C, Weindruch R, Fernandez JR, Coffey CS, Patel P, Allison DB. Caloric restriction and body weight ...