Mouse Models in Aging Research - The Mouse in Biomedical Research (Second Edition) - Chapter 20In invertebrates, the molecular genetic pathways that regulate life span and senescence are being identified; surprisingly, they are conserved through evolution. In mice, specific genes that can increase ...
Mouse Models in Aging Research-Chapter 20 Aging is defined as the progressive decline in functional reserve that occurs in all organisms over time. Aging causes a decrease in the capacity of tissue... K Flurkey,JM Currer,DE Harrison 被引量: 0发表: 0年 Transgenic mouse models for studying ...
Telomeres, the ends of eukaryotic chromosomes, protect genome integrity and enable cell proliferation. Maintaining optimal telomere length in the germline and throughout life limits the risk of cancer and enables healthy aging. Telomeres in the house mouse,Mus musculus, are about five times longer th...
Reporter proteins have become an indispensable tool in biomedical research. However, exogenous introduction of these reporters into mice poses a risk of rejection by the immune system. Here, we describe the generation, validation and application of a mul
Progeroid mouse models display phenotypes in multiple organ systems that suggest premature aging and resemble features of natural aging of both mice and hu... Harkema,S A,Youssef,... - 《Veterinary Pathology》 被引量: 23发表: 2016年 The vascular endothelial growth factor family; proteins which ...
Furthermore, we demonstrated that MSC-derived exosomes migrate to specific neuropathological locations in rodent models for stroke, Parkinson's disease, Alzheimer’s disease (AD), spinal cord injury, and ASD. Interestingly, in the BTBR ASD model, the MSC-exo migrated to the frontal cortex and...
Whether CD147 serves as a functional receptor for SARS-CoV-2 infection is widely debated in the field of COVID-19 research. In this study, we generated two novel knock-in mouse models in the NSG background for: (1) hACE2, the putative receptor for SARS-CoV-2 entry (hACE2KI-NSG),...
Accordingly, antisense oligonucleotides (ASOs) and RNA interference (RNAi) have been used to knock down the expression of mutant SOD1 and improve therapeutic outcomes in animal models of the disorder.13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24 However, owing to their transient ...
Neutrophils are frequently studied in mouse models, but the extent to which findings translate to humans remains poorly defined. In an integrative analysis of 11 mouse and 13 human datasets, we find a strong correlation of neutrophil gene expression across species. In inflammation, neutrophils display...
HGPS, a debilitating premature aging disease whose features strikingly resemble the accelerated aspects of normal aging, represents a paradigm for translational medicine in the arena of aging research33. The complex nature of this segmental syndrome makes it difficult to target therapeutically, with stand...