Aging Research Using Mouse Models. Curr Protoc Mouse Biol 2015;5:95-133.Ackert-Bicknell CL, Anderson LC, Sheehan S, Hill WG, Chang B, Churchill GA, Chesler EJ, Korstanje R, Peters LL (2015) Aging research using mouse models. Curr Protoc Mouse Biol 5(2):95-133. https://doi.org/...
Aging Research Using Mouse Models Despite the dramatic increase in human lifespan over the past century, there remains pronounced variability in "health-span," or the period of time in whic... CL Ackert-Bicknell,LC Anderson,S Sheehan,... - 《Current Protocols in Mouse Biology》 被引量: 8...
Female reproductive system aging has consequences for fertility and overall health. In this Review, the authors provide a comprehensive overview of the biological process of female reproductive aging based on research with physiologic aging mouse models, and describe the mechanisms that underlie these phe...
Using mouse and human plasma, Carver et al. identify factors that are altered with age and test which are reverted by a panel of genetic and pharmacological senolytic interventions in aged mice. They identify IL-23R as a senescence-associated, age-increased circulating biomarker. ...
Research on aging has been conducted using various models from yeast and nematode to mouse and non-human primates, and has rapidly progressed due to the recent development of forward and reverse genetics, as well as functional genomics. Some mouse models bearing artificially or naturally modified ...
[224], mouse [225], sheep [226] and cow [227] which means a need for further evaluation of the research results on human body. Moreover, since most of the studies done on human are focused on the influence of kinds of miRNAs on ovarian pathologies like PCOS [228], POF [227] or ...
Figure 1.Premeiotic germ cells persist in aged atrophic mouse ovaries.(A) Analysis of germline marker gene expression in ovaries of young adult (2-month) and aged (20-month) female mice. Results from all 4 mice per age group are shown (β-actin, housekeeping gene used as a sample loadin...
There it is, one consumer well-publicized survey after another, whether it is the WSJ, Pew Research or AARP, even as adoption in business, healthcare and other industries grows. Consumers continue to express worry – but in the meantime…82% of companies are either using or exploring use ...
A study from Ortega-Molina and colleagues uses mouse models with mildly elevated mTOR activity to investigate the stepwise process by which increased nutrient signaling affects healthy aging. These findings show how initial parenchymal damage caused by mTOR activity is followed by secondary myeloid inflam...
Using mouse and human plasma, Carver et al. identify factors that are altered with age and test which are reverted by a panel of genetic and pharmacological senolytic interventions in aged mice. They identify IL-23R as a senescence-associated, age-increased circulating biomarker. ...