1)Aged mice老年小鼠 1.Angiogenesis stimulated by platelet-derived growth factor in aged mice;血小板衍生生长因子在老年小鼠新血管生成中的作用 2.Objective:To study the immune regulation effect of water extract of Fructus Comus (FC) in aged mice to explore its mechanism in retarding aging.目的:研究...
Identification of the characteristics of allogeneic immune responses in aging mice may offer important information for transplantation immunology. The major age-related changes in the immune cell phenotypes and function of 12 months old mice include: 1) the significantly decreased CD4+ cell population ...
Objective Given that ovarian secretion of progestins declines with aging, whether or not senescent mice are responsive to progestins was of interest. Methods Homozygous PR knockout (PRKO) or wild-type mice that were between 10–12 (mid-aged) or 20–24 (aged) months of age were administered...
Female fecundity decreases one to two decades before the menopausal transition. A study by Zhang et al. now identifies aging-related decline of the polyamine spermidine as a crucial bottleneck for oocyte quality. Supplementation with spermidine rejuvenat
The present study examined the effect of aging on female reproductive potential.Six-week-old and 9-month-old CD1 mice were referred to as the 'young' and 'aged' groups, respectively. Oocytes were collected after superovulation, and their viability were compared using parthenogenetic activation. Th...
Aging leads to decreased skeletal muscle function in mammals and is associated with a progressive loss of muscle mass, quality and strength. Age-related muscle loss (sarcopenia) is an important health problem associated with the aged population. We inves
Young adult (6 months) and mid-aged (12 months) C57BL/6 mice both learned to discriminate ethanol (ETOH, 1.0 g/kg) although criterion performance occurred later for mid-aged mice. ETOH discrimination improved with increasing dose (0.25-1.0 g/kg) and the dose-response function was unaffected...
DNA methylation profiles of young mice housed in ENR or STD for four days (Young ENR; Young STD; n = 5) and aged mice housed in ENR or STD for one year (aged ENR; Aged STD; n = 7) as determined by RRBS. a Aging decreases global CpG methylation in STD but not in ENR...
then fail to maintain the follicle reserve with advancing age. Herein we used mice as a model to further test whether changes in premeiotic germ cell function might be an important variable to at least consider in the context of understanding the mechanisms involved in ovarian aging in mammals....
We show that FMT from between young and aged mice replaced the recipient microbiota composition with a composition resembling the donor, enriched for particular bacterial species, and altered the metabolic potential of the resulting gut microbial composition. Our results demonstrate that the aging microbi...