Since γδT17 cells are suspected to be pro-tumorigenic [2], the authors next compared how mice of different age coped with an experimental lung cancer challenge and found impaired anti-tumor responses in old mice. Based on these observations, they propose a link between changes of the ...
1)Aged mice老年小鼠 1.Angiogenesis stimulated by platelet-derived growth factor in aged mice;血小板衍生生长因子在老年小鼠新血管生成中的作用 2.Objective:To study the immune regulation effect of water extract of Fructus Comus (FC) in aged mice to explore its mechanism in retarding aging.目的:研究...
Similarly, attempts have been made to treat aged mice ovaries with resveratrol, an anti-aging molecule [23, 24]. In comparison to age-matched control which produced no pups, young mice fed with resveratrol for 12 months were found to retain capacity to reproduce. They had greater number of ...
Showing a notable decrease of blood vessel density (left) and a reduction in the number of tip cells (right, arrows) with reproductive aging. d Quantifying the number of tip cells showed a notable decline of angiogenesis with reproductive aging (4 M: n = 7 mice, 8 M: n =...
Maternal fertility declines irreversibly with aging, and advanced maternal age is mostly related to impaired oocyte quality. The flavonol compound quercetin is considered to be an anti-aging agent due to its cytoprotective actions as an antioxidant. Howe
Female fecundity decreases one to two decades before the menopausal transition. A study by Zhang et al. now identifies aging-related decline of the polyamine spermidine as a crucial bottleneck for oocyte quality. Supplementation with spermidine rejuvenat
In vitro experiments, CatK−/− impaired bone-derived c-Kit+ cellular functions (migration, invasion, proliferation, and tubulogenesis) in aged mice. Our findings demonstrated that aging impaired the ischemia-induced angiogenesis associated with the reductions of the production and mobilization of ...
Metformin, a type 2 diabetes treatment, improves the cognitive function of aged mice; however, whether the protective effects of metformin on cognitive function in aged mice are associated with the gut microbiome is poorly understood. Although some studies suggest that the gut microbe composition infl...
Ageing is a complex multifactorial process associated with a plethora of disorders, which contribute significantly to morbidity worldwide. One of the organs significantly affected by age is the gut. Age-dependent changes of the gut-associated microbiome
aged mice, as well as in cultured neurons. We performed a targeted lipidomic analysis on an AD-vulnerable brain region (entorhinal cortex; EC) and an AD-resistant brain region (primary visual cortex; PVC) from 14–15 month-oldAPOE3/3,APOE3/4, andAPOE4/4targeted replacement mice, as ...