The frequency of gene conversion events in MHC class II genes varies strongly from one MHC haplotype to another, with the highest detected frequencies as high as 1/40 000 for an individual heterozygous for both donor and acceptor sequences. Deletions or insertions in one gene relative to the ...
Molecular analyses of genes in the rabbit MHC (RLA) by pulsed field gel electrophoresis have shown that the relative order of class II genes (DP, DO, DQ, DR) is identical to that in humans and similar to that in the mouse. However, a maj... L Chouchane,TJ Kindt - 《Journal of Imm...
Whether protection against injury is due to the MHC induction or to other effects of IFN-γ (i.e., induction of endothelial protective genes) is not known. The GRKO allografts at day 7 showed greatly reduced MHC class I and II induction in the graft, and had reduced infiltration by ...
Although the MHC class II genes are known to be regulated transcriptionally, the relative rates of transcription of the four classical class II genes in different cell types have not been investigated. Using nuclear transcriptional analysis, we have investigated the transcriptional rates of the class ...
et al. Mice lacking all conventional MHC class II genes. Proc. Natl Acad. Sci. USA 96, 10338–10343 (1999). CAS PubMed PubMed Central Google Scholar Kobata, A. The third chains of living organisms-a trail of glycobiology that started from the third floor of building 4 in NIH. Arch...
MHC class II – Evolution – Polymorphism – Mouse lemur – BAC sequencingWe here report the genomic organisation of the grey mouse lemur ( Microcebus murinus ) MHC class II DQ and DR region based on BAC clone analysis. The sequenced Mimu-MHC haplotype spans 343kb and encompasses the genes ...
Our previous studies indicated that in the CTS mouse, class II MHC was the same as that of the NOD mouse, but that class I MHC was different at both K and D loci, and that CTS MHC was diabetogenic in the presence of NOD background genes. These data map major genetic susceptibility ...
产品类型:流式抗体 品牌:Bio-Rad 货号:MCA45PE 规格:100 Tests 价格:3970 抗原:MHC Class II RT1Bu/L 物种:大鼠 宿主:小鼠 抗体亚型:IgG1 克隆号:OX-3 荧光染料:PE 产品介绍 技术参数 相关产品 产品介绍 产品介绍 Mouse anti Rat MHC Class II RT1Bu/L antibody, clone OX-3 recognizes a polymorphic...
(2007) studied selection on two MHC class II genes in vole populations with fluctuating density and found much stronger geographic hetero- geneity in selection signal at the DQA gene than the DRB. Second, differences in selection may also occur between orthologues, that is, genes at the same ...
The most telomeric class I region of the MHC in rat and mouse is the M region, which contains about 20 class I genes or gene fragments. The central part carries three class I genes— M4, M5 , and M6 —which are orthologous between the two species. M4 and M6 are pseudogenes in the ...