The frequency of gene conversion events in MHC class II genes varies strongly from one MHC haplotype to another, with the highest detected frequencies as high as 1/40 000 for an individual heterozygous for both donor and acceptor sequences. Deletions or insertions in one gene relative to the ...
Selection and recombination drive the evolution of MHC class II DRB diversity in ungulates Major histocompatibility complex (MHC) antigen-presenting genes are the most variable loci in vertebrate genomes. Host-parasite co-evolution is assumed to ... H Schaschl,P Wandeler,F Suchentrunk,... - 《...
et al. Mice lacking all conventional MHC class II genes. Proc. Natl Acad. Sci. USA 96, 10338–10343 (1999). CAS PubMed PubMed Central Google Scholar Kobata, A. The third chains of living organisms-a trail of glycobiology that started from the third floor of building 4 in NIH. Arch...
MHC class II – Evolution – Polymorphism – Mouse lemur – BAC sequencingWe here report the genomic organisation of the grey mouse lemur ( Microcebus murinus ) MHC class II DQ and DR region based on BAC clone analysis. The sequenced Mimu-MHC haplotype spans 343kb and encompasses the genes ...
产品类型:流式抗体 品牌:Bio-Rad 货号:MCA45PE 规格:100 Tests 价格:3970 抗原:MHC Class II RT1Bu/L 物种:大鼠 宿主:小鼠 抗体亚型:IgG1 克隆号:OX-3 荧光染料:PE 产品介绍 技术参数 相关产品 产品介绍 产品介绍 Mouse anti Rat MHC Class II RT1Bu/L antibody, clone OX-3 recognizes a polymorphic...
Our previous studies indicated that in the CTS mouse, class II MHC was the same as that of the NOD mouse, but that class I MHC was different at both K and D loci, and that CTS MHC was diabetogenic in the presence of NOD background genes. These data map major genetic susceptibility ...
The most telomeric class I region of the MHC in rat and mouse is the M region, which contains about 20 class I genes or gene fragments. The central part carries three class I genes— M4, M5 , and M6 —which are orthologous between the two species. M4 and M6 are pseudogenes in the ...
(2007) studied selection on two MHC class II genes in vole populations with fluctuating density and found much stronger geographic hetero- geneity in selection signal at the DQA gene than the DRB. Second, differences in selection may also occur between orthologues, that is, genes at the same ...
These include MHC Class II genes required for efficient Sag presentation, the innate immune pathogen sensor toll-like receptor 4 (Tlr4), and several as-of-yet unidentified genes that affect the production of anti-MMTV antibodies or T cell responses to MMTV (reviewed in [43]). MMTV infection ...
et al. A novel DNA-binding regulatory factor is mutated in primary MHC class II deficiency (bare lymphocyte syndrome). Genes Dev. 9, 1021–1032 (1995) CAS PubMed Google Scholar Sun, H., Tsunenari, T., Yau, K. W. & Nathans, J. The vitelliform macular dystrophy protein defines a ...