A high-resolution transcriptomic and spatial atlas of cell types in the whole mouse brain Article Open access 13 December 2023 Main High-throughput single-cell RNA sequencing (scRNA-seq) revealed hundreds of molecularly distinct cell types across the entire mouse and human nervous system1,2,3,4...
In this paper, we describe a single-cell RNA sequencing (scRNA-seq) dataset that defines vascular and vessel-associated cell types and subtypes in mouse brain and lung. The dataset contains 3,436 single cell transcriptomes from mouse brain, which formed 15 distinct clusters corresponding to cell...
function and disorders. Although single-cell RNA sequencing (scRNA-seq) has revealed the complexity and diversity of cell-type composition in the mouse brain
Development of the mammalian brain requires precise molecular changes across diverse cell lineages. While single-cell RNA abundances in the developing brain have been characterized by single-cell RNA sequencing (scRNA-seq), single-cell protein abundances
For lineage tracing, barcoded cells could be sorted using EGFP and subjected to scRNA-seq, and edited arrays from both recorders in single cells could be recovered。所以他们这个系统的优势就在于,1.是dual recorder系统,可以增加barcode的多样性。2.是具有cre-restricted的labeing,可以具体聚焦于某一个...
We performed a comprehensive survey of the adolescent mouse nervous system by scRNA-seq. We dissected the brain and spinal cord into contiguous anatomical regions and further included the peripheral sensory, enteric, and sympathetic nervous system. In total, we analyzed 19 regions (Figure 1A) but ...
The brain was collected on post-stroke day 7. Associated videos are available in the supplemental materials Full size image Initial assessment of scRNA-seq data on microglia from male and female mouse brains after permanent stroke We then asked two questions: how does permanent stroke impact the ...
To begin, we employed scRNA-seq to understand the cell-type landscape of the ATN (Figure 1A). To do this, the ATN was first identified using gross cytoarchitecture and microdissected from brain slices (Figure 1B; n = 3 animals total, with anterior, intermediate, and posterior brain section...
First, dissociating adult brain into healthy, representative cell suspensions is difficult; many scRNA-seq studies have thus used younger mice, in which developmental programs are comingled with the expression differences that underlie functional specializations. Here, we developed techniques, borrowing ...
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