(CSF-1), HPSCs differentiate into macrophages through various multipotent progenitor stages: granulocyte/macrophage colony-forming unit (GM-CFU) to monocyte colony-forming unit (M-CFU) to monoblasts to promonocytes. After being released into the blood stream, promonocytes give rise to monocytes. ...
a crucial step towards establishing autologous transplantation of genome-edited cells for GD. We use the RNP/AAV6 platform to achieve efficient integration of GCase cassettes into the CCR5 safe harbor locus. By leveraging a lineage-specific promoter highly expressed in the monocyte/macrophage lineage,...
Innate immunity, in particular the monocyte/macrophage system, has rarely been studied in this disorder, although alterations in microglia indicate a role for this system. Increased monocyte numbers have repeatedly been described. Toll-like receptors (TLRs) mediate the activation of monocytes. We ...
Moreover, as main finding of this work, well in agreement with the emerging notion that monocyte/macrophage activation can play a pivotal causative role in the inflammatory disorder characterizing severe COVID-191,2,3,4,5,6,7,8, here we show that MDW can serve as novel prognostic biomarker...
(Supplementary Fig.1b), consistent with prior reports linking macrophage cholesterol depletion with pro-inflammatory cytokine production26,27. In contrast, mTORi was not found to transcriptionally modulateTNFexpression among LPS-stimulated monocytes (Fig.3c). These results align with observations at the...
(Fig.5A). By using the mouse macrophage-specific marker, Mac-3, we found significant increases in numbers of cells stained for this marker in the secondary spongiosae after cPTH infusion in WT mice but low staining in MCP-1−/−mice even after cPTH infusion, demonstrating that MCP-1 ...
sensitized wild-type mice. In contrast, regardless of donor CD4+T-cells from wild-type or CCR2−/−mice sensitized with MOG peptide, CCR2−/−recipient mice failed to develop EAE due to reduced T-cell and macrophage infiltration into the spinal cord. These results suggest that CCR2 ...
Although we here did not observe an interaction effect on specific genes, it is therefore tempting to speculate that CA is linked to suicidal ideation through a long-lasting activation of the monocyte/macrophage system, possibly involving inflammatory compounds and/or the MAPK pathway. Trained ...
Osteoarthritis (OA) is a chronic joint disorder characterized by slow progressive degeneration of articular cartilage, subchondral bone alteration, and variable secondary synovial inflammation. In response to macrophage-derived proinflammatory cytokines such as interleukin (IL)-1β and tumor necrosis factor-...
Hoshino Y, Hatake K, Kasahara T, Takahashi Y, Ikeda M, Tomizuka H, Ohtsui T, Uwai M, Mukaida N, Matsushima K (1995) Monocyte chemoattractant protein-1 stimulates tumor necrosis and recruitment of macrophages into tumors in tumor-bearing nude mice: increased granulocyte and macrophage progenito...